NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Rebecca WardAdviye Ergul

Abstract

Diabetes increases the risk and worsens the progression of cognitive impairment via the greater occurrence of small vessel disease and stroke. Yet, the underlying mechanisms are not fully understood. It is now accepted that cardiovascular health is critical for brain health and any neurorestorative approaches to prevent/delay cognitive deficits should target the conceptual neurovascular unit (NVU) rather than neurons alone. We have recently shown that there is augmented hippocampal NVU remodeling after a remote ischemic injury in diabetes. NLRP3 inflammasome signaling has been implicated in the development of diabetes and neurodegenerative diseases, but little is known about the impact of NLRP3 activation on functional and structural interaction within the NVU of hippocampus, a critical part of the brain that is involved in forming, organizing, and storing memories. Endothelial cells are at the center of the NVU and produce trophic factors such as brain derived neurotrophic factor (BDNF) contributing to neuronal survival, known as vasotrophic coupling. Therefore, the aims of this study focused on two hypotheses: 1) diabetes negatively impacts hippocampal NVU remodeling and worsens cognitive outcome after stroke, and 2) NLRP3 in...Continue Reading

Citations

Jun 9, 2019·Journal of Neuroinflammation·Pu HongHong-Fei Zhang
Mar 3, 2020·Canadian Journal of Physiology and Pharmacology·Yasir AbdulAdviye Ergul
Jul 25, 2019·International Journal of Molecular Sciences·Farzane SivandzadeLuca Cucullo
Jun 26, 2020·Frontiers in Cellular Neuroscience·Ya-Shuo FengFeng Zhang
Sep 20, 2020·Cell Death & Disease·Baochen BaiXian-Ming Chu
Jan 9, 2021·Molecular Neurobiology·Ernest T ChiveroShilpa Buch
Feb 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Karine Paula ReichertMaria Rosa Chitolina Schetinger
Apr 4, 2021·International Journal of Molecular Sciences·Aleksandra KaliszewskaNatalia Arias
Apr 28, 2021·The International Journal of Neuroscience·Larissa Silva JoaquimFabricia Petronilho
May 30, 2020·Current Neuropharmacology·Ruiqing KangJohn H Zhang
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chu LinLinong Ji
Aug 28, 2021·Biomolecules·Sophie CoyleVictoria McGilligan
Nov 21, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lian LiuBo Zhao
Feb 25, 2021·CNS & Neurological Disorders Drug Targets·Ghaith A Bahadar, Zahoor A Shah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.