NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity

Frontiers in Immunology
Marina SokolovaArne Yndestad

Abstract

Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be activated in response to endogenous danger signals and triggers activation of interleukin (IL)-1β and IL-18. Increasing evidence points to the involvement of the NLRP3 inflammasome in obesity-induced inflammation and insulin resistance, and we hypothesized that it also could play a role in the development of obesity induced cardiac alterations. Methods and Results: WT, Nlrp3-/-, and ASC-/- (Pycard-/-) male mice were exposed to high fat diet (HFD; 60 cal% fat) or control diet for 52 weeks. Cardiac structure and function were evaluated by echocardiography and magnetic resonance imaging, respectively. Whereas, NLRP3 and ASC deficiency did not affect the cardiac hypertrophic response to obesity, it was preventive against left ventricle concentric remodeling and impairment of diastolic function. Furthermore, whereas NLRP3 and ASC deficiency attenuated systemic inflammation in HFD fed mice; long-term HFD did not induce significant cardiac fibrosis or inflammation, suggesting that the beneficial effects of NLRP3 infla...Continue Reading

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Citations

Dec 4, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Serena L'AbbateClaudia Kusmic
Sep 29, 2020·Frontiers in Psychology·Marek JankowskiJolanta Gutkowska
Mar 29, 2020·Frontiers in Physiology·Gaia FaveroRita Rezzani
Aug 27, 2021·European Journal of Nutrition·Thanutchaporn KumrungseeNorihisa Kato
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang

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Methods Mentioned

BETA
ELISA
Assay
Protein Assay

Software Mentioned

GraphPad Prism
Vevo 2100
GraphPad
ImageJ

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