NLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19.

Frontiers in Immunology
Alberto López-ReyesGabriela Angélica Martínez-Nava

Abstract

Several countries around the world have faced an important obesity challenge for the past four decades as the result of an obesogenic environment. This disease has a multifactorial origin and it is associated with multiple comorbidities including type 2 diabetes, hypertension, osteoarthritis, metabolic syndrome, cancer, and dyslipidemia. With regard to dyslipidemia, hypertriglyceridemia is a well-known activator of the NLRP3 inflammasome, triggering adipokines and cytokines secretion which in addition induce a systemic inflammatory state that provides an adequate scenario for infections, particularly those mediated by viruses such as HIV, H1N1 influenza, and SARS-CoV-2. The SARS-CoV-2 infection causes the coronavirus disease 2019 (COVID-19) and it is responsible for the pandemic that we are currently living. COVID-19 causes an aggressive immune response known as cytokine release syndrome or cytokine storm that causes multiorgan failure and in most cases leads to death. In the present work, we aimed to review the molecular mechanisms by which obesity-associated systemic inflammation could cause a more severe clinical presentation of COVID-19. The SARS-CoV-2 infection could potentiate or accelerate the pre-existing systemic infla...Continue Reading

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Citations

Mar 7, 2021·Nutrients·Jean-Pascal De Bandt, Charlotte Monin
Feb 23, 2021·Frontiers in Pharmacology·Bohao LiuQing Geng
Mar 31, 2021·Scandinavian Journal of Immunology·Juan Bautista De SanctisMarián Hajduch
May 11, 2021·World Journal of Gastroenterology : WJG·Isabela Macedo Lopes Vasques-Monteiro, Vanessa Souza-Mello
Jun 29, 2021·Advanced Drug Delivery Reviews·Danielle BrainNeill J Liptrott
Jun 22, 2021·Frontiers in Molecular Biosciences·Hongliang ZhangJinhui Tao
Aug 28, 2021·Biomolecules·Naiara Naiana DejaniDamião Pergentino de Sousa

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Methods Mentioned

BETA
ubiquitination

Clinical Trials Mentioned

NCT04326790
NCT04322565
NCT04328480
NCT04322682
NCT04339816
NCT04336332
NCT04409522
NCT04362813
NCT04348448
NCT04365153

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