NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease

Frontiers in Immunology
Pierre-Grégoire CoulonLbachir BenMohamed

Abstract

The crosstalk between the host's inflammasome system and the invading virulent/less-virulent viruses determines the outcome of the ensuing inflammatory response. An appropriate activation of inflammasomes triggers antiviral inflammatory responses that clear the virus and heal the inflamed tissue. However, an aberrant activation of inflammasomes can result in a harmful and overwhelming inflammation that could damage the infected tissue. The underlying host's immune mechanisms and the viral virulent factors that impact severe clinical inflammatory disease remain to be fully elucidated. In this study, we used herpes simplex virus type 1 (HSV-1), the causative agent of corneal inflammatory herpetic disease, as a model pathogen to determine: (i) Whether and how the virulence of a virus affects the type and the activation level of the inflammasomes; and (ii) How triggering specific inflammasomes translates into protective or damaging inflammatory response. We showed that, in contrast to the less-virulent HSV-1 strains (RE, F, KOS, and KOS63), corneal infection of B6 mice with the virulent HSV-1 strains (McKrae, 17 or KOS79): (i) Induced simultaneous expression of the NLRP3, NLRP12, and IFI16 inflammasomes; (ii) Increased production o...Continue Reading

References

Jan 30, 2002·Ocular Immunology and Inflammation·T L KeadleP M Stuart
Mar 3, 2004·The Journal of Biological Chemistry·Nobuko FujiuchiToru Ouchi
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min XuRobert L Hendricks
Aug 1, 2006·Investigative Ophthalmology & Visual Science·Andrew J LepistoRobert L Hendricks
Apr 20, 2007·Journal of Leukocyte Biology·Mohamed LamkanfiGabriel Núñez
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Sherrie J Divito, Robert L Hendricks
Jun 28, 2008·Seminars in Ophthalmology·Yoshitsugu Inoue
Sep 10, 2008·The Journal of Experimental Medicine·Daniel R GettsNicholas J C King
Mar 9, 2010·Investigative Ophthalmology & Visual Science·Gregory M FrankRobert L Hendricks
Mar 31, 2010·Nature Immunology·Vijay A K RathinamKatherine A Fitzgerald
Sep 18, 2010·Nature Reviews. Immunology·Thirumala-Devi Kanneganti
Sep 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janelle C ArthurJenny P-Y Ting
Oct 5, 2010·Nature Immunology·Leonie UnterholznerAndrew G Bowie
Nov 19, 2011·Cancer Cell·Md Hasan ZakiThirumala-Devi Kanneganti
Jan 21, 2012·Methods in Molecular Biology·Olaf Gross
May 15, 2012·Journal of Leukocyte Biology·Sarah R Jacobs, Blossom Damania
Jun 16, 2012·Future Virology·Xavier DervillezLbachir Benmohamed
Oct 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Megan H OrzalliDavid M Knipe
Sep 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Swati ShahVolker Briken
Sep 27, 2013·Journal of Virology·Eui Tae KimMatthew D Weitzman
Dec 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Md Hasan ZakiThirumala-Devi Kanneganti
Jan 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Devin M WestPatrick M Stuart
May 21, 2014·Annals of the New York Academy of Sciences·Fayyaz S SutterwalaSuzanne L Cassel
May 31, 2014·Biology of Reproduction·Weiwei ZhuDaishu Han
Nov 19, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·David P SesterKatryn J Stacey
Mar 17, 2015·Current Opinion in Virology·Christopher LupferThirumala-Devi Kanneganti
Apr 17, 2015·Immunological Reviews·Eric I Elliott, Fayyaz S Sutterwala
Jun 28, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·David P SesterKatryn J Stacey

❮ Previous
Next ❯

Citations

Jun 17, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pierre-Grégoire CoulonLbachir BenMohamed
Jul 14, 2020·Immunological Reviews·Timur LiwinskiEran Elinav
Oct 2, 2020·Microbiology and Molecular Biology Reviews : MMBR·Huifang Zhu, Chunfu Zheng
Oct 13, 2020·Frontiers in Cellular and Infection Microbiology·Austin M Jeffries, Ian Marriott
Nov 24, 2019·Life Sciences·Ramesh Chandra Rai
Jul 25, 2021·International Journal of Molecular Sciences·Young-Su Yi
Nov 8, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qiang FuXiaoxia Zhan

❮ Previous
Next ❯

Methods Mentioned

BETA
PMA
Infection
FACS
ELISA
ELISAs
flow cytometry
flow-cytometry
electrophoresis
acetylation
co-immunoprecipitation

Software Mentioned

Image Lab (
Fiji
ImageJ
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.