NLS-mediated NPC functions of the nucleoporin Pom121

FEBS Letters
Sevil YavuzWolfram Antonin

Abstract

RanGTP mediates nuclear import and mitotic spindle assembly by dissociating import receptors from nuclear localization signal (NLS) bearing proteins. We investigated the interplay between import receptors and the transmembrane nucleoporin Pom121. We found that Pom121 interacts with importin alpha/beta and a group of nucleoporins in an NLS-dependent manner. In vivo, replacement of Pom121 with an NLS mutant version resulted in defective nuclear transport, induction of aberrant cytoplasmic membrane stacks and decreased cell viability. We propose that the NLS sites of Pom121 affect its function in NPC assembly both by influencing nucleoporin interactions and pore membrane structure.

References

Dec 28, 1999·Annual Review of Cell and Developmental Biology·D Görlich, U Kutay
Jul 27, 2000·Molecular Cell·M HetzerI W Mattaj
Mar 26, 2003·The Journal of Cell Biology·Kathryn J RyanSusan R Wente
Aug 2, 2003·Nature·Tobias C WaltherMartin Hetzer
Oct 11, 2003·Molecular Biology of the Cell·Amnon HarelDouglass J Forbes
Mar 31, 2006·Nature·Petr KalábKarsten Weis
May 17, 2006·The Journal of Cell Biology·Fabrizia StavruDirk Görlich
Nov 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Beth A RasalaDouglass J Forbes
Sep 11, 2007·Nature Cell Biology·Daniel J Anderson, Martin W Hetzer
Mar 5, 2008·The Journal of Cell Biology·Elisa DultzJan Ellenberg
Jul 4, 2008·Molecular Biology of the Cell·Beth A RasalaDouglass J Forbes

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Citations

May 4, 2013·Trends in Biochemical Sciences·Andrea Rothballer, Ulrike Kutay
Apr 20, 2011·Cold Spring Harbor Symposia on Quantitative Biology·M CapelsonM W Hetzer
Sep 19, 2014·Molecular Biology of the Cell·Robert MahenJan Ellenberg
Jul 10, 2012·Current Opinion in Cell Biology·Naoko Imamoto, Tomoko Funakoshi
Feb 8, 2011·Current Opinion in Cell Biology·Evgeny Onischenko, Karsten Weis
Jan 30, 2013·Traffic·Anne C MeinemaLiesbeth M Veenhoff
Oct 2, 2015·Journal of Molecular Biology·Anna Katharina SchellhausWolfram Antonin
May 6, 2015·Nucleus·Brant M Webster, C Patrick Lusk
Jul 17, 2015·Molecular Biology of the Cell·Annemarie KraltLiesbeth M Veenhoff
May 23, 2012·Nucleus·Anne C MeinemaLiesbeth M Veenhoff
Feb 18, 2014·Current Opinion in Cell Biology·Justyna K LabaLiesbeth M Veenhoff
Jan 26, 2017·Nature Reviews. Molecular Cell Biology·Rosemarie Ungricht, Ulrike Kutay
Dec 21, 2019·Expert Review of Molecular Diagnostics·Tengqi WangLizhou Jia
Nov 20, 2016·Journal of Cell Science·Marion Weberruss, Wolfram Antonin
Dec 10, 2020·Genetic Testing and Molecular Biomarkers·Shidong ZhangShengkui Tan
Feb 7, 2021·International Journal of Biological Macromolecules·Denzelle Lee LyngdohTimir Tripathi
Jun 6, 2015·Journal of Cell Science·Greg Kabachinski, Thomas U Schwartz
Aug 1, 2015·Journal of Cell Science·Allana SchooleyWolfram Antonin
Dec 24, 2013·Journal of Cell Science·Nathalie EisenhardtWolfram Antonin
Jun 22, 2021·Cancer Biomarkers : Section a of Disease Markers·Lirong GuanKun Zhao
May 21, 2016·Genes & Development·Tobias M FranksMartin W Hetzer

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