PMID: 16531762Mar 15, 2006Paper

NM-23 gene loss of heterozygosity and protein expression in high-stage laryngeal squamous cell carcinomas

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
Hina SheikhJennifer L Hunt

Abstract

Tumor suppressor genes that reduce metastatic potential have been described in a variety of different tumor types. One of the main tumor metastasis suppressor genes is nm-23, which is a nucleoside diphosphate kinase. Two isotypes, nm-23H1 and nm-23H2, have been cloned and map to chromosome 17q21.3. In a variety of tumors, including colon cancer and breast cancer, loss of expression of nm-23 is associated with lymph node metastasis. In other organ systems, however, this relationship is not seen. In head and neck squamous cell carcinomas (HNSCC), there have been conflicting results regarding the association between nm-23 protein expression and metastatic potential. To further explore the tumor metastasis suppressor function of nm-23 in HNSCC, we studied high-stage laryngeal carcinomas, tumors with and without cervical lymph node metastasis for nm-23 protein expression and loss of heterozygosity of the gene locus. Twenty-five cases were included (11 cases with and 14 cases without metastasis). Loss of heterozygosity for the nm-23 gene locus was seen in 7 of 22 (32%) informative tumors. Using immunohistochemistry, most tumors expressed nm-23, though decreased expression was seen in 10 of 25 (40%) cases. Only 2 tumors showed negativ...Continue Reading

References

Mar 1, 1994·The Journal of Pathology·J A RoydsT J Stephenson
May 5, 1993·Journal of the National Cancer Institute·J A RoydsP B Silcocks
May 4, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·K PavelićR Spaventi
Jan 5, 2002·Head & Neck·H T HoffmanT M McCulloch
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Yuesheng JinFredrik Mertens
Dec 13, 2002·Head & Neck·Allison Carter Ford, Jennifer Rubin Grandis
Jan 22, 2003·Virchows Archiv : an International Journal of Pathology·Alfons Nadal, Antonio Cardesa
May 9, 2003·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·David Hardisson
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Eiji SuzukiNobuyoshi Shimizu
Mar 30, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Robbert J C SlebosJack A Taylor
May 20, 2004·British Journal of Cancer·Y-F WangL-S Wang
Nov 26, 2004·Journal of Clinical Pathology·S KapitanovićR Spaventi

❮ Previous
Next ❯

Citations

Jul 22, 2008·Otolaryngologia polska. The Polish otolaryngology·Adam IdasiakRafał Suwiński
Jan 17, 2012·International Journal of Systematic and Evolutionary Microbiology·Marta MartiniBojan Duduk
Mar 26, 2015·American Journal of Clinical Oncology·Antonella FlaccoLucio Crinò
Sep 25, 2009·The British Journal of Dermatology·J Reichrath

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.