NM23 as a prognostic biomarker in ovarian serous carcinoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Bo Sung YounNam Hoon Cho

Abstract

The nm23 gene is a reported metastasis suppressor gene. Recent studies have shown that its expression has tissue specificity. The role of nm23 in human ovarian cancer is still controversial. This study examines the prognostic significance of nm23 expression in patients with serous ovarian carcinoma. Following comparative proteomics in 13 fresh frozen ovarian serous cancer tissues with other histological types of ovarian cancers, validation was performed using immunohistochemistry on clinically well-designed 73 ovarian serous carcinoma microarray samples that were retrieved from ovarian cancer patients from 1990 to 2003. Statistical analysis of the results was performed using chi(2) test, Cox proportional regression, the Kaplan-Meier method and log-rank test. We found that the expression of nm23 inversely correlated with peritoneal seeding (P=0.009). However, strong nm23 expression was associated with mortality in patients with ovarian carcinoma in univariate analysis (P=0.04). Poor prognostic factors of disease-free survival included tumor residue more than 2 cm (P=0.02), bilaterality (P=0.01) and peritoneal seeding (P<0.01), whereas poor prognostic factors affecting overall survival included peritoneal seeding (P=0.05). In Kap...Continue Reading

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Citations

Oct 31, 2012·International Journal of Molecular Sciences·Kentaro NakayamaKohji Miyazaki
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Maria Giuseppina BarattaDavid M Livingston
Dec 9, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Huixin YaoZhuchu Chen
Apr 28, 2011·Nature Reviews. Clinical Oncology·Alexander N ShoushtariCarrie W Rinker-Schaeffer
Feb 23, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Wei HanHou-Zhong Ding

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