PMID: 22358100Feb 24, 2012Paper

NMDA and AMPA receptors are involved in the antidepressant-like activity of tianeptine in the forced swim test in mice

Pharmacological Reports : PR
Piotr WlaźEwa Poleszak

Abstract

It is known that tianeptine exhibits antidepressant-like activity. Its influence on the glutamatergic system is also known, but the mechanisms involved in this activity remain to be established. The aim of this study was to investigate the involvement of the glutamate pathway in the antidepressant-like action of tianeptine. We investigated the effects of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor ligands on tianeptine-induced activity in the forced swim test (FST) in mice. The antidepressant-like activity of tianeptine (30 m/kg, ip) was significantly antagonized by D-serine (100 nmol/mouse icv) and NBQX (10 mg/kg, ip). Moreover, low, ineffective doses of the glycine/NMDA site antagonist L-701,324 (1 mg/kg, ip) administered together with low, ineffective doses of tianeptine (20 mg/kg, ip) exhibited a significant reduction of immobility time in the FST. These doses of the examined agents, which did have an effect in the FST, did not alter locomotor activity. The present study indicates that the antidepressant-like activity of tianeptine in the FST involves both NMDA and AMPA receptors and suggests that the interaction between serotonergic and glutamatergic transmission may pl...Continue Reading

References

Oct 1, 1990·Trends in Pharmacological Sciences·J WillettsJ D Leander
Nov 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·T MenniniS Garattini
Dec 1, 1980·Journal of Pharmacological Methods·J J Lipman, P S Spencer
Aug 1, 1994·Neuropharmacology·J P Kelly, B E Leonard
Nov 1, 1993·The American Journal of Psychiatry·C A AltamuraF Zamberlan
Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Apr 4, 2000·Biological Psychiatry·J LevineJ W Pettegrew
Jun 19, 2001·Neuropharmacology·X LiP Skolnick
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·F BaiP Skolnick
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Per SvenningssonPaul Greengard
Jun 27, 2003·Cellular and Molecular Neurobiology·Xia LiPhil Skolnick
Nov 20, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bruce S McEwen, Sumantra Chattarji
May 17, 2005·Current Pharmaceutical Design·A AltD Bleakman
Jan 5, 2006·The American Journal of Psychiatry·Carlos A ZarateDennis S Charney
Jan 31, 2006·Biochemical Pharmacology·Andrew AltJeffrey M Witkin
Aug 9, 2006·Archives of General Psychiatry·Carlos A ZarateHusseini K Manji
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jing DuHusseini K Manji
Apr 14, 2007·CNS & Neurological Disorders Drug Targets·Christopher PittengerJohn H Krystal
Apr 14, 2007·CNS & Neurological Disorders Drug Targets·D BleakmanJ M Witkin
Apr 21, 2007·Journal of Neural Transmission·E Poleszak
Dec 20, 2007·The European Journal of Neuroscience·Per SvenningssonPaul Greengard
Jan 4, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sanjay J MathewDennis S Charney
Apr 22, 2008·Nature Reviews. Drug Discovery·Gerard SanacoraHusseini K Manji
Aug 16, 2008·The Mount Sinai Journal of Medicine, New York·Srijan Sen, Gerard Sanacora
Oct 20, 2009·Trends in Pharmacological Sciences·Phil SkolnickRamon Trullas

❮ Previous
Next ❯

Citations

Dec 3, 2014·Pharmacological Reports : PR·Ewa PoleszakPiotr Wlaź
Sep 15, 2014·Neuroscience and Biobehavioral Reviews·Mehdi GhasemiAhmad Salehi
May 9, 2014·Brain Structure & Function·Maryam GhafariGert Lubec
Jun 19, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ewa PoleszakPiotr Wlaź
Jun 9, 2016·Expert Opinion on Drug Metabolism & Toxicology·Monika BanachStanisław J Czuczwar
Mar 2, 2012·Expert Opinion on Investigational Drugs·Chun YangJianjun Yang
Dec 15, 2012·Pharmacological Reports : PR·Kinga K BorowiczStanisław J Czuczwar
Jun 18, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zheng MouJun-Tian Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.