NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome

Current Opinion in Pharmacology
Kian Fan Chung

Abstract

Chronic cough is a common symptom that can be difficult to treat. It is proposed to be part of a cough hypersensitivity syndrome characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure. Upper airway and laryngeal neural dysfunction may also be present. There is evidence that this hypersensitivity may be due to sensory nerve damage caused by inflammatory, infective and allergic factors. Antitussive therapies based on opioid medications are generally not efficacious. Antagonists of N-methyl-d-aspartate receptors in the brain stem and use of GABAB receptor agonists such as baclofen acting centrally and possibly peripherally may represent novel therapeutic approaches.

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Citations

Sep 6, 2015·Pulmonary Pharmacology & Therapeutics·Kian Fan ChungLorcan McGarvey
May 22, 2016·Medicina clínica·Adalberto Pacheco
Dec 29, 2016·Pharmacogenetics and Genomics·Seyed H MahmoudpourUNKNOWN PREDICTION-ADR consortium
May 28, 2017·Respiratory Physiology & Neurobiology·Donatella Mutolo
Jul 13, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elenia CinelliDonatella Mutolo
Sep 24, 2015·Current Opinion in Otolaryngology & Head and Neck Surgery·Laura M Dominguez, C Blake Simpson
May 15, 2018·American Journal of Respiratory and Critical Care Medicine·Kian Fan Chung
May 31, 2019·The European Respiratory Journal·Lorcan McGarveyUNKNOWN NEUROCOUGH Clinical Research Collaboration
Mar 30, 2020·MMW Fortschritte der Medizin·Ludger Klimek, Peter Kardos
May 7, 2020·Current Opinion in Pharmacology·Brijeshkumar S PatelY S Prakash
May 15, 2021·American Journal of Speech-language Pathology·Mary J SandageShelby C Odom

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