NMDA and GABAA receptors in the rat Kolliker-Fuse area control cardiorespiratory responses evoked by trigeminal ethmoidal nerve stimulation

The Journal of Physiology
Mathias Dutschmann, H Herbert

Abstract

1. Electrical stimulation (10 s) of the ethmoidal nerve (EN5) evokes the nasotrigeminal reflex responses, including apnoea, bradycardia and rise in arterial blood pressure. In the present study, we examined the involvement of N-methyl-D-aspartate (NMDA), AMPA/kainate, (gamma-aminobutyric acidA (GABAA) and glycine receptors in the Kolliker-Fuse (KF) nucleus in the mediation of the nasotrigeminal reflex responses. 2. Unilateral injections (n = 6) of 50-100 nl of the NMDA receptor antagonist AP5 into the KF area led to a significant blockade of the EN5-evoked respiratory depression and bradycardia. Injections placed into the midlevel of the KF area were most effective (80-90 % blockade). The rise in arterial blood pressure remained unaffected. 3. Unilateral injections (n = 6) of the AMPA/kainate receptor antagonist CNQX into the KF area failed to block EN5-evoked autonomic responses significantly. 4. Unilateral injections (n = 5) of the GABAA receptor antagonist bicuculline enhanced the EN5-evoked respiratory depression and bradycardia. The effect persisted for up to 30 s after stimulation. Bicuculline injections into the midlevel of the KF area were most effective. The increase in arterial blood pressure remained unaffected. 5. U...Continue Reading

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Citations

May 28, 2005·Respiratory Physiology & Neurobiology·Christian GestreauArmand Louis Bianchi
Jul 11, 2002·Respiratory Physiology & Neurobiology·Mathias Dutschmann, Julian F R Paton
Nov 26, 2003·Respiratory Physiology & Neurobiology·Diethelm W Richter
Nov 15, 2002·Journal of Anatomy·Julian F R Paton, Mathias Dutschmann
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Mörschel, Mathias Dutschmann
Nov 3, 2004·Respiratory Physiology & Neurobiology·Mingchen JiangDonald R McCrimmon
Apr 19, 2015·Respiratory Physiology & Neurobiology·Zhenzhong BaiAurélien P Pichon
Aug 29, 2006·Respiratory Physiology & Neurobiology·Miodrag RadulovackiDavid W Carley
Dec 31, 2009·Respiratory Physiology & Neurobiology·N VoituronG Hilaire
Sep 2, 2011·Journal of Child Neurology·Fleming S PedrosoNewra T Rotta
Nov 3, 2004·Respiratory Physiology & Neurobiology·Miodrag RadulovackiDavid W Carley
Jul 16, 2008·Respiratory Physiology & Neurobiology·Mathias DutschmannMiriam Kron
Dec 23, 2003·The Journal of Comparative Neurology·Fabrice RodaChristian Gestreau
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Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mathias Dutschmann, Julian F R Paton
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Nov 7, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miroslav RozloznikMathias Dutschmann
Apr 5, 2016·Veterinary Surgery : VS·Michael CarusoRobert Henry
Jul 4, 2020·Pflügers Archiv : European journal of physiology·Nafiseh Mirzaei-DamabiAli Nasimi
Dec 9, 2003·Journal of Applied Physiology·Brian J KoosLawrence Kruger
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Jun 15, 2021·Respiratory Physiology & Neurobiology·Edward J ZuperkuAstrid G Stucke
Jul 21, 2009·Respiratory Physiology & Neurobiology·Akiko Arata

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