PMID: 9178845May 9, 1997Paper

NMDA and non-NMDA receptors are co-localized at excitatory synapses of rat hypoglossal motoneurons

Neuroscience Letters
J A O'BrienA J Berger

Abstract

We used whole-cell patch clamp recordings in a rat brainstem slice preparation to characterize the properties of miniature excitatory postsynaptic currents (mEPSCs) in hypoglossal motoneurons. The distinct kinetic characteristics of N-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated synaptic responses allowed us to study dual component mEPSCs mediated by the two receptor types. Using this approach, NMDA and non-NMDA receptors were found to be co-localized at the same synaptic locations. In addition, some sites contain only NMDA receptors since a large proportion of mEPSCs were apparently mediated by NMDA receptors only. Furthermore, the amplitudes of pharmacologically isolated NMDA receptor-mediated mEPSCs were highly variable in individual cells and their decay kinetics were modulated by membrane potential.

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Citations

Sep 1, 2000·Respiration Physiology·A J Berger
Apr 2, 1999·The European Journal of Neuroscience·N K Mahanty, P Sah
Mar 9, 2011·Respiratory Physiology & Neurobiology·Albert J Berger
Apr 29, 2005·Journal of Neurochemistry·I PaarmannM Hollmann
Aug 27, 2005·The Journal of Physiology·Marat MukhtarovPiotr Bregestovski
Jul 4, 2012·The Journal of Physiology·Walter E BabiecJack L Feldman
Jun 13, 2003·Clinics in Chest Medicine·Sigrid Carlen Veasey
Oct 20, 2015·Brain Structure & Function·Refik KanjhanMark C Bellingham
Jan 25, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V BaptistaW A Varanda
Mar 4, 2005·Journal of Neurophysiology·Vander Baptista, Wamberto Antonio Varanda
Aug 30, 2013·American Journal of Physiology. Cell Physiology·Xiao-Tao JinChun Jiang
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Dec 22, 1999·Journal of Neurophysiology·M B Lips, B U Keller
Apr 30, 1999·Physiological Reviews·G Hilaire, B Duron
Dec 24, 1998·Journal of Neurophysiology·A J BergerP Ascher

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