NMDA channel regulation by channel-associated protein tyrosine kinase Src

Science
X M YuMichael W Salter

Abstract

The N-methyl-D-aspartate (NMDA) receptor mediates synaptic transmission and plasticity in the central nervous system (CNS) and is regulated by tyrosine phosphorylation. In membrane patches excised from mammalian central neurons, the endogenous tyrosine kinase Src was shown to regulate the activity of NMDA channels. The action of Src required a sequence [Src(40-58)] within the noncatalytic, unique domain of Src. In addition, Src coprecipitated with NMDA receptor proteins. Finally, endogenous Src regulated the function of NMDA receptors at synapses. Thus, NMDA receptor regulation by Src may be important in development, plasticity, and pathology in the CNS.

References

Sep 1, 1992·Trends in Neurosciences·S O Meakin, E M Shooter
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G M DurandR S Zukin
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·I S MoonM B Kennedy
Apr 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Superti-Furga, S A Courtneidge
Aug 25, 1995·The Journal of Biological Chemistry·L F Lau, R L Huganir
Oct 27, 1995·Science·H Thoenen
Apr 1, 1993·Trends in Neurosciences·L A RaymondR L Huganir
Jul 1, 1994·Physiological Reviews·C J McBain, M L Mayer
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y T WangM W Salter

❮ Previous
Next ❯

Citations

Oct 20, 1998·Journal of Neurobiology·S Finkbeiner, M E Greenberg
Aug 31, 2002·Angewandte Chemie·K ZouH Bayley
Aug 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Finkbeiner, M E Greenberg
Jul 2, 2003·Neurotoxicity Research·Thomas N ChaseJustin D Oh
Feb 3, 2012·Pflügers Archiv : European journal of physiology·Shuang FengXian-Min Yu
Apr 12, 2008·Purinergic Signalling·Kazuhide InoueSchuichi Koizumi
Apr 12, 2008·Purinergic Signalling·Kazuhide Inoue
Dec 8, 2011·Bulletin of Mathematical Biology·Max R BennettWilliam G Gibson
Jul 27, 2007·Cell Biochemistry and Biophysics·Toshihiro TakataShan Ping Yu
Jan 27, 2004·Biochemical and Biophysical Research Communications·Yasuhiro TsunodaFumihiko Nozu
Oct 31, 2003·Trends in Neurosciences·Angela L Purcell, Thomas J Carew
Nov 20, 2003·Trends in Neurosciences·Ru-Rong JiClifford J Woolf
Sep 10, 2003·Biochemical Pharmacology·Michelle M Aarts, Michael Tymianski
Oct 17, 1998·Biochemical Pharmacology·M W Salter
Aug 12, 1999·European Journal of Pharmacology·F CattabeniM Di Luca
Oct 8, 2003·Neuropharmacology·Lorraine V Kalia, Michael W Salter
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Jul 17, 1998·Trends in Pharmacological Sciences·S Fletcher, N M Barnes
Feb 1, 2000·Trends in Neurosciences·T R Soderling, V A Derkach
May 13, 1999·Brain Research. Molecular Brain Research·H S Kalluri, M K Ticku
Oct 16, 1999·Brain Research. Molecular Brain Research·H KawachiM Noda
Aug 28, 1999·Progress in Neurobiology·T Yamakura, K Shimoji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.