Abstract
NMDA receptor channel plays an important role in the pathophysiological process of traumatic brain injury (TBI). The present study aims to study the pathological mechanism of TBI and the impairment of learning and memory after TBI, and to investigate the mechanism of the protective effect of NMDA receptor antagonist MK-801 on learning and memory disorder after TBI. Forty Sprague-Dawley rats (weighing approximately 200 g) were randomized into 5 groups (n = 8 in each group): control group, model group, low-dose group (MK-801 0.5 mg/kg), middle-dose group (MK-801 2 mg/kg), and high-dose group (MK-801 10 mg/kg). TBI model was established using a weight-drop head injury mode. After 2-month drug treatment, learning and memory ability was evaluated by using Morris water maze test. Then the animals were sacrificed, and brain tissues were taken out for morphological and immunohistochemical assays. The ability of learning and memory was significantly impaired in the TBI model animals. Besides, the neuronal caspase-3 expression, neuronal nitric oxide synthase (nNOS)-positive neurons and OX-42-positive microglia were all increased in TBI animals. Meanwhile, the number of neuron synapses was decreased, and vacuoles degeneration could be obs...Continue Reading
References
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Dec 1, 1993·Brain Research. Cognitive Brain Research·R J HammB G Lyeth
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·T LiuG Z Feuerstein
Apr 8, 1996·The Journal of Comparative Neurology·L AcarinA J Castro
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T R SairanenA L Sirén
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg
Mar 10, 1999·Brain : a Journal of Neurology·S LoveG K Wilcock
Nov 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P L Huang
Mar 10, 2000·Journal of Neurotrauma·M OehmichenH G König
May 17, 2001·Journal of Neurosurgery·J F StoverA W Unterberg
May 23, 2001·Brain Research·S RavishankarM Delivoria-Papadopoulos
Aug 16, 2001·Brain & Development·A IshidaM V Johnston
Oct 10, 2001·Neuroscience·A E KlineC E Dixon
Mar 6, 2003·Brain Research·Xueren ZhaoCostantino Iadecola
Aug 5, 2003·Experimental Neurology·Virginie Beray-BerthatIsabelle Margaill
Dec 4, 2003·Brain Research·Kristin K HagaMichael J O'Neill
Feb 18, 2004·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·D L Heath, R Vink
Aug 7, 2004·Experimental Neurology·J H KimJ E Lee
Feb 26, 2005·Neurosurgery·Barbara TavazziRoberto Vagnozzi
Aug 15, 2006·Journal of the International Neuropsychological Society : JINS·Rodger L Wood, Neil A Rutterford
Sep 1, 2006·Developmental Neuroscience·Courtney L RobertsonGary Fiskum
Sep 9, 2006·Journal of Neurotrauma·Suat Erol CelikSahsine Tolunay
May 25, 2007·Brain Injury : [BI]·Marcela Lippert-GrünerChristoph Wedekind
Aug 23, 2007·Journal of Neurotrauma·Nino StocchettiElisa R Zanier
Citations
Aug 3, 2013·Cell Death & Disease·J M FarookN Sen
Mar 22, 2014·PloS One·Paul A MullerAlexander Rotenberg
Jan 2, 2014·International Journal of Molecular Sciences·Hanna Algattas, Jason H Huang
Jul 6, 2013·Regenerative Medicine·Eric M GoldBrian J Cummings
May 6, 2014·Cellular and Molecular Neurobiology·Zi-Hui DengGuang-Tao Yan
Dec 10, 2014·Journal of Neurotrauma·Nicole D OsierC Edward Dixon
Mar 31, 2016·Zebrafish·Victoria McCutcheonAndrew J Baker
May 7, 2015·Neuroscience Letters·Ataç SönmezMeryem Çalişir
Oct 9, 2014·Journal of Bioenergetics and Biomembranes·Tyler G Demarest, Margaret M McCarthy
May 12, 2016·Progress in Neurobiology·Anthony E KlineCorina O Bondi
Sep 2, 2016·Frontiers in Neurology·Nicole D Osier, C Edward Dixon
Sep 22, 2016·Journal of Neurotrauma·Victoria McCutcheonAndrew J Baker
Dec 10, 2016·Journal of Neurotrauma·Naomi S Sta MariaChristopher C Giza
Nov 1, 2012·Bulletin of Experimental Biology and Medicine·Z I StorozhevaV V Sherstnev
Jan 29, 2020·Cerebral Cortex·Wenrui QuXiao-Ming Xu
May 6, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cuiping GuoXiaochuan Wang
Aug 10, 2018·Chinese Journal of Integrative Medicine·Ji Hye HwangYong-Ki Park
Oct 13, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Karen-Amanda Irvine, J David Clark
Aug 9, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Mao-Sheng FangYi Li
Dec 21, 2018·Neuroscience Bulletin·Lin XuXiu-Lan Zhao
Nov 6, 2014·Experimental and Therapeutic Medicine·Qiang ZhangSheng Sun
Dec 7, 2016·Pharmacological Reports : PR·Vinoth K M KhandelwalManu Chaudhary
Jul 11, 2019·Neural Regeneration Research·Nan-Xing YiTing Zhang
Oct 29, 2020·Neuroscience Bulletin·Jianing LuoYan Qu
May 6, 2019·Experimental Neurology·Naomi S Sta MariaChristopher C Giza
Jun 8, 2021·Neuropeptides·Ayse CigelAtac Sonmez
Dec 16, 2016·ACS Chemical Neuroscience·Sonu SinghShubha Shukla
Oct 16, 2021·Journal of Neurosurgery·Ian MasseLouis De Beaumont