NMDA receptor antagonist MK-801 reduces neuronal damage and preserves learning and memory in a rat model of traumatic brain injury.

Neuroscience Bulletin
Rui-Zhang HanYi Huang

Abstract

NMDA receptor channel plays an important role in the pathophysiological process of traumatic brain injury (TBI). The present study aims to study the pathological mechanism of TBI and the impairment of learning and memory after TBI, and to investigate the mechanism of the protective effect of NMDA receptor antagonist MK-801 on learning and memory disorder after TBI. Forty Sprague-Dawley rats (weighing approximately 200 g) were randomized into 5 groups (n = 8 in each group): control group, model group, low-dose group (MK-801 0.5 mg/kg), middle-dose group (MK-801 2 mg/kg), and high-dose group (MK-801 10 mg/kg). TBI model was established using a weight-drop head injury mode. After 2-month drug treatment, learning and memory ability was evaluated by using Morris water maze test. Then the animals were sacrificed, and brain tissues were taken out for morphological and immunohistochemical assays. The ability of learning and memory was significantly impaired in the TBI model animals. Besides, the neuronal caspase-3 expression, neuronal nitric oxide synthase (nNOS)-positive neurons and OX-42-positive microglia were all increased in TBI animals. Meanwhile, the number of neuron synapses was decreased, and vacuoles degeneration could be obs...Continue Reading

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·T LiuG Z Feuerstein
Apr 8, 1996·The Journal of Comparative Neurology·L AcarinA J Castro
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T R SairanenA L Sirén
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg
Mar 10, 1999·Brain : a Journal of Neurology·S LoveG K Wilcock
Nov 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P L Huang
Mar 6, 2003·Brain Research·Xueren ZhaoCostantino Iadecola
Aug 5, 2003·Experimental Neurology·Virginie Beray-BerthatIsabelle Margaill
Feb 18, 2004·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·D L Heath, R Vink
Aug 15, 2006·Journal of the International Neuropsychological Society : JINS·Rodger L Wood, Neil A Rutterford
Sep 1, 2006·Developmental Neuroscience·Courtney L RobertsonGary Fiskum
Sep 9, 2006·Journal of Neurotrauma·Suat Erol CelikSahsine Tolunay
May 25, 2007·Brain Injury : [BI]·Marcela Lippert-GrünerChristoph Wedekind
Aug 23, 2007·Journal of Neurotrauma·Nino StocchettiElisa R Zanier

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Citations

Jan 2, 2014·International Journal of Molecular Sciences·Hanna Algattas, Jason H Huang
Jul 6, 2013·Regenerative Medicine·Eric M GoldBrian J Cummings
May 7, 2015·Neuroscience Letters·Ataç SönmezMeryem Çalişir
Oct 9, 2014·Journal of Bioenergetics and Biomembranes·Tyler G Demarest, Margaret M McCarthy
Nov 1, 2012·Bulletin of Experimental Biology and Medicine·Z I StorozhevaV V Sherstnev
May 6, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cuiping GuoXiaochuan Wang
Oct 13, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Karen-Amanda Irvine, J David Clark
Aug 9, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Mao-Sheng FangYi Li
Dec 7, 2016·Pharmacological Reports : PR·Vinoth K M KhandelwalManu Chaudhary
Jul 11, 2019·Neural Regeneration Research·Nan-Xing YiTing Zhang
May 6, 2019·Experimental Neurology·Naomi S Sta MariaChristopher C Giza

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