NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus

British Journal of Pharmacology
J HarveyG L Collingridge

Abstract

1. The depression of synaptic transmission by the specific metabotropic glutamate receptor (mGlu) agonist (1S, 3R)-1-aminocyclopentane-1,3-dicarboxylate ((1S,3R)-ACPD) was investigated in area CA1 of the hippocampus of 4-10 week old rats, by use of grease-gap and intracellular recording techniques. 2. In the presence of 1 mM Mg2+, (1S,3R)-ACPD was a weak synaptic depressant. In contrast, in the absence of added Mg2+, (1S,3R)-ACPD was much more effective in depressing both the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) and N-methyl-D-aspartate (NMDA) receptor-mediated components of synaptic transmission. At 100 microM, (1S,3R)-ACPD depressed the slope of the field excitatory postsynaptic potential (e.p.s.p.) by 96 +/- 1% (mean +/- s.e.mean; n = 7) compared with 23 +/- 4% in 1 mM Mg(2+)-containing medium (n = 17). 3. The depressant action of 100 microM (1S,3R)-ACPD in Mg(2+)-free medium was reduced from 96 +/- 1 to 46 +/- 6% (n = 7) by the specific NMDA receptor antagonist (R)-2-amino-5-phosphonopentanoate (AP5; 100 microM). 4. Blocking both components of GABA receptor-mediated synaptic transmission with picrotoxin (50 microM) and CGP 55845A (1 microM) in the presence of 1 mM Mg2+ also enhanced the depressant act...Continue Reading

References

Nov 11, 1991·Neuroscience Letters·G J Pacelli, S R Kelso
Oct 1, 1994·The European Journal of Neuroscience·C L BoultonG L Collingridge
Sep 1, 1994·Trends in Pharmacological Sciences·J Watkins, G Collingridge
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Sep 1, 1995·British Journal of Pharmacology·C H DaviesG L Collingridge
Nov 1, 1995·Neuropharmacology·V Y Bolshakov, S A Siegelbaum
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Dec 1, 1995·The European Journal of Neuroscience·O Manzoni, J Bockaert
May 1, 1994·Pflügers Archiv : European journal of physiology·A LüthiU Gerber

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Citations

Oct 24, 2007·Molecular Neurobiology·Brad A GrueterDanny G Winder
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Jul 23, 1999·Progress in Neurobiology·F Bordi, A Ugolini
Jun 28, 2016·Neuroscience and Biobehavioral Reviews·Crystal BostromBrian R Christie

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