NMDA receptor regulation of cell death in the rat olfactory bulb

Journal of Neurobiology
B K Fiske, P C Brunjes

Abstract

Cell death is widespread in the developing nervous system and is under complex regulation by numerous intra- and intercellular mechanisms. Blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor has been shown to promote cell death in the developing brain (Ikonomidou et al., 1999), suggesting that afferent functional activation is an important regulator of cell survival. The olfactory bulb, the first central relay for olfactory information from the nose, is well suited for examining the role of afferent activity in neuronal development. Functional deprivation is easily performed by surgical blockade of airflow to one side of the nasal passage, which results in dramatic alterations in postnatal development of the bulb (Brunjes, 1994), including enhanced neuronal loss (Frazier and Brunjes, 1988; Najbauer and Leon, 1995). The present report examined the specific role of NMDA receptor activation in regulating cell survival within the rat bulb. Pharmacological blockade of receptors with the noncompetitive channel blocker MK-801 (3 x 0.5 mg/kg i.p.) resulted in profound increases in cell death within 24 h. Furthermore, in contrast to other regions, where the effects of receptor blockade were confined to the first 2 ...Continue Reading

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Citations

Jul 10, 2004·Journal of Physiology, Paris·Armen SaghatelyanPierre-Marie Lledo
Aug 23, 2003·Brain Research·Carol Ho-Wing Leung, Donald A Wilson
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Sep 29, 2004·The Journal of Comparative Neurology·Jennifer M MirichPeter C Brunjes

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