NMDA receptor subunits are phosphorylated by activation of neurotrophin receptors in PSD of rat spinal cord

Neuroreport
M Di LucaC Missale

Abstract

We have investigated the distribution of NMDA and neurotrophin receptor systems and their reciprocal interactions in post-synaptic densities (PSD) purified from spinal cord. NMDA receptor subunits, trkA and trkB, but not trkC, were present in spinal cord PSD. The incubation of PSD with BDNF and NGF induced the phosphorylation of NR2A and B subunits. This phosphorylation was counteracted by antibodies directed against the catalytic domain of trkA and trkB receptors and by genistein. These results suggest the existence of a previously unexplored cross-talk between neurotrophins and NMDA receptors in rat spinal cord neurons.

References

Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·I S MoonM B Kennedy
Aug 25, 1995·The Journal of Biological Chemistry·L F Lau, R L Huganir
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Aug 1, 1996·Current Opinion in Cell Biology·M D EhlersR L Huganir
Dec 31, 1996·Brain Research. Molecular Brain Research·K WuI B Black
Jun 1, 1997·Trends in Neurosciences·M B Kennedy
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·P C SuenI B Black

❮ Previous
Next ❯

Citations

Oct 30, 2004·Synapse·John E KolbEric S Levine
May 15, 2008·Experimental Brain Research·Peter SvenssonBrian E Cairns
Feb 19, 2003·Brain Research. Brain Research Reviews·Sophie PezetStephen B McMahon
Feb 28, 2002·The European Journal of Neuroscience·V L Arvanian, L M Mendell
Feb 19, 2002·The European Journal of Neuroscience·T B RomanczykJ E Kleinman
Jun 1, 2005·Molecular and Cellular Biology·Kausik ChakrabartiMartin R Schiller
Jun 25, 2005·The Journal of Comparative Neurology·Sarah E SlackSophie Pezet
Nov 22, 2005·Brain Research·Marcelo O DietrichLuis V Portela
Dec 18, 2013·Neuroscience Letters·Larisa R Collins, Nancy S Koven
Mar 24, 2004·Spinal Cord·J F DitunnoA S Burns
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick J G H KamphuisVictor M Wiegant

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.