NMDA receptor subunits change in the prefrontal cortex of pure-opioid and multi-drug abusers: a post-mortem study

European Archives of Psychiatry and Clinical Neuroscience
Hamidreza DaneshparvarMohammad-Reza Zarrindast

Abstract

Addiction is a chronic relapsing disorder and is one of the most important issues in the world. Changing the level of neurotransmitters and the activities of their receptors, play a major role in the pathophysiology of substance abuse disorders. It is well-established that N-methyl-D-aspartate receptors (NMDARs) play a significant role in the molecular basis of addiction. NMDAR has two obligatory GluN1 and two regionally localized GluN2 subunits. This study investigated changes in the protein level of GluN1, GluN2A, and GluN2B in the prefrontal cortex of drug abusers. The medial prefrontal cortex (mPFC), lateral prefrontal cortex (lPFC), and orbitofrontal cortex (OFC) were dissected from the brain of 101 drug addicts brains and were compared with the brains of non-addicts (N = 13). Western blotting technique was used to show the alteration in NMDAR subunits level. Data obtained using Western blotting technique showed a significant increase in the level of GluN1 and GluN2B, but not in GluN2A subunits in all the three regions (mPFC, lPFC, and OFC) of men whom suffered from addiction as compared to the appropriate controls. These findings showed a novel role for GluN1, GluN2B subunits, rather than the GluN2A subunit of NMDARs, in ...Continue Reading

References

Dec 1, 1977·The British Journal of Addiction to Alcohol and Other Drugs·E Kaufman
Jan 1, 1976·The American Journal of Drug and Alcohol Abuse·E Kaufman
Oct 6, 1997·Science·G F Koob, M Le Moal
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·D J MayerD D Price
Jul 23, 1999·Annals of the New York Academy of Sciences·B J EverittT W Robbins
Jul 25, 2000·Journal of Psychoactive Drugs·M D AnglinS Dawud-Noursi
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Feb 3, 2006·Journal of Neuroscience Research·Michal BajoGeorge Robert Siggins
Nov 16, 2006·Annals of the New York Academy of Sciences·Maria Filomena BotelhoTice Macedo
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Takanori MutoHisato Jingami
Oct 20, 2007·Nature Reviews. Neuroscience·Julie A Kauer, Robert C Malenka
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryan T LaLumiere, Peter W Kalivas
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jamie PetersPeter W Kalivas
Nov 11, 2008·Annals of the New York Academy of Sciences·T W RobbinsB J Everitt
Apr 22, 2009·Learning & Memory·Jamie PetersGregory J Quirk
Jul 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Debra K CozzoliKaren K Szumlinski
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Nov 26, 2009·Neuroscience and Biobehavioral Reviews·Michel C Van den OeverTaco J De Vries
Jan 19, 2010·Pharmacological Reports : PR·Bartosz Bobula, Grzegorz Hess
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Mar 15, 2011·The European Journal of Neuroscience·Pierre Paoletti
Sep 7, 2012·Cold Spring Harbor Perspectives in Medicine·Jamie Peters, Taco J De Vries
Aug 24, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Debra K CozzoliKaren K Szumlinski
Oct 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roy A Wise, George F Koob
Jan 6, 2015·The Journal of Physiology·Nathan G GlasgowJon W Johnson
Aug 1, 2016·The Lancet. Psychiatry·George F Koob, Nora D Volkow
Jul 16, 2017·Drug and Alcohol Dependence·Candice E CrockerPhilip G Tibbo

❮ Previous
Next ❯

Citations

Dec 5, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ti-Fei Yuan, Amit Etkin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.