NMDA receptors expressed in oligodendrocytes

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Richard Wong

Abstract

Oligodendrocytes are known to express (Ca2+)-permeable glutamate receptors and to have low resistance to oxidative stress, two factors that make them potentially susceptible to injury. Oligodendrocyte injury is intrinsic to the loss of function experienced in conditions ranging from cerebral palsy to spinal cord injury, focal ischaemia and multiple sclerosis. NMDA receptors, a subtype of glutamate receptors, are vital to the remodeling of synaptic connections during postnatal development and associative learning abilities in adults and possibly in improvements in oligodendrocyte function. Previous studies had failed to detect NMDA receptor mRNA or current in oligodendrocytes but three new papers demonstrate NMDA receptor expression in oligodendrocytes and discuss its implications for ischaemia therapy.

References

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Citations

Dec 15, 2010·PloS One·Ming-Chak LeeGilles J Guillemin
Nov 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Juan Carlos de Rivero VaccariRoderick A Corriveau
May 29, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Abolfazl Azami TamehHomayoun Naderian
Apr 4, 2008·Trends in Pharmacological Sciences·Elaine BesanconEng H Lo
Oct 19, 2011·Journal of Neurochemistry·Rachel WilliamsSteven M LeVine
Jul 11, 2012·International Journal of Cell Biology·Vincent BerezowskiJérôme Badaut
Oct 2, 2012·Journal of Neuroimmunology·Shivika RaiRakesh Shukla
Oct 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·U Sh KuzminaYu V Vakhitova

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