NMR ((1)H and (13)C) based signatures of abnormal choline metabolism in oral squamous cell carcinoma with no prominent Warburg effect

Biochemical and Biophysical Research Communications
Swarnendu BagJyotirmoy Chatterjee

Abstract

At functional levels, besides genes and proteins, changes in metabolome profiles are instructive for a biological system in health and disease including malignancy. It is understood that metabolomic alterations in association with proteomic and transcriptomic aberrations are very fundamental to unravel malignant micro-ambient criticality and oral cancer is no exception. Hence deciphering intricate dimensions of oral cancer metabolism may be contributory both for integrated appreciation of its pathogenesis and to identify any critical but yet unexplored dimension of this malignancy with high mortality rate. Although several methods do exist, NMR provides higher analytical precision in identification of cancer metabolomic signature. Present study explored abnormal signatures in choline metabolism in oral squamous cell carcinoma (OSCC) using (1)H and (13)C NMR analysis of serum. It has demonstrated down-regulation of choline with concomitant up-regulation of its break-down product in the form of trimethylamine N-oxide in OSCC compared to normal counterpart. Further, no significant change in lactate profile in OSCC possibly indicated that well-known Warburg effect was not a prominent phenomenon in such malignancy. Amongst other imp...Continue Reading

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Oct 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E LouisL Mesotten
Apr 30, 2016·Expert Reviews in Molecular Medicine·Jyoti Chhibber-GoelAmit Sharma
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Sep 28, 2021·Applied Microbiology and Biotechnology·Rekha JalandraPratima R Solanki

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