NMR assignments of the N-terminal signaling domain of the TonB-dependent outer membrane transducer PupB.

Biomolecular NMR Assignments
Jaime L JensenChristopher L Colbert

Abstract

Outer membrane TonB-dependent transducers (TBDTs) actively transport ferric siderophore complexes from the extracellular environment into Gram-negative bacteria. They also participate in a cell-surface signaling regulatory pathway that results in upregulation of the transducer itself, in response to iron-deplete conditions. The TBDT PupB transports ferric pseudobactin, and signals through its N-terminal signaling domain (NTSD), while the TBDT homolog PupA is signaling-inactive. Here, we report the NMR chemical shift assignments of the PupB-NTSD. This information will provide the basis for structural characterization of the PupB-NTSD to further explore its signaling properties.

References

Jun 1, 1978·Journal of Bacteriology·R J Kadner, G McElhaney
Nov 1, 1995·Journal of Biomolecular NMR·F DelaglioA Bax
Jul 5, 2005·Trends in Microbiology·Ralf Koebnik
Jan 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrew D FergusonJohann Deisenhofer
Sep 28, 2007·Journal of Biomolecular NMR·Simon W GinzingerVolker Heun
Jul 4, 2009·Journal of Biomolecular NMR·Simon W GinzingerVolker Heun
Sep 1, 1994·Journal of Biomolecular NMR·B A Johnson, R A Blevins

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Citations

Feb 29, 2020·The Journal of Biological Chemistry·Jaime L JensenChristopher L Colbert
Feb 1, 2021·The Journal of Biological Chemistry·Jaime L JensenChristopher L Colbert

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