NMR-Based Chemosensing via p-H2 Hyperpolarization: Application to Natural Extracts

Analytical Chemistry
Niels HermkensMarco Tessari

Abstract

When dealing with trace analysis of complex mixtures, NMR suffers from both low sensitivity and signal overlap. NMR chemosensing, in which the association between an analyte and a receptor is "signaled" by an NMR response, has been proposed as a valuable analytical tool for biofluids and natural extracts. Such chemosensors offer the possibility to simultaneously detect and distinguish different analytes in solution, which makes them particularly suitable for analytical applications on complex mixtures. In this study, we have combined NMR chemosensing with nuclear spin hyperpolarization. This was realized using an iridium complex as a receptor in the presence of parahydrogen: association of the target analytes to the metal center results in approximately 1000-fold enhancement of the NMR response. This amplification allows the detection, identification, and quantification of analytes at low-micromolar concentrations, provided they can weakly associate to the iridium chemosensor. Here, our NMR chemosensing approach was applied to the quantitative determination of several flavor components in methanol extracts of ground coffee.

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Citations

Oct 19, 2016·Magnetic Resonance in Chemistry : MRC·Julien Wist
Feb 10, 2017·Journal of Magnetic Resonance·Niels K J HermkensMarco Tessari
Jan 10, 2018·Angewandte Chemie·Peter J Rayner, Simon B Duckett
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Jun 6, 2019·Chemical Communications : Chem Comm·Lisanne SelliesMarco Tessari
Jul 3, 2016·Magnetic Resonance in Chemistry : MRC·Patrick Giraudeau
Aug 9, 2016·Magnetic Resonance in Chemistry : MRC·Jean-Nicolas Dumez
Jan 17, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara Pacholczyk-SienickaŁukasz Albrecht
Feb 25, 2021·Chemical Communications : Chem Comm·Federico De BiasiFederico Rastrelli
Apr 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Thomas B R RobertsonRyan E Mewis
May 26, 2021·Food Chemistry·Elisabetta SchievanoMarco Tessari
Jan 6, 2018·Analytical Chemistry·Jonathan FarjonPatrick Giraudeau
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Aug 19, 2021·Magnetic Resonance in Chemistry : MRC·Daniel A TaylorRalph W Adams
Dec 16, 2021·Chemical Communications : Chem Comm·Kerti AusmeesIndrek Reile

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