NMR-based metabonomic analysis of normal rat urine and faeces in response to (±)-venlafaxine treatment

Journal of Pharmaceutical and Biomedical Analysis
José I Serrano-ContrerasLuis G Zepeda-Vallejo

Abstract

(±)-Venlafaxine, a bicyclic antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class, is prescribed for the treatment of depression and anxiety disorders. As is the case with other antidepressants, its precise mechanisms of action are still unknown. Pharmacometabonomic approaches allow for the detection of diverse metabolites, unlike classic methods for analysing drug interaction based on single metabolites and linear pathways. This provides a global view of the state of homeostasis during treatment and an insight into the mechanisms of action of a drug. Accordingly, the final outcome of treatment is characterised by the network of reactome pathways derived from the on-target and off-target effects of the drug. Regarding antidepressants, the drug network may be located in the gut-microbiome-brain-liver-kidney-immune-cardiovascular system axis (GMBLKICA), implying that neurotransmitters participate as signalling molecules in bidirectional communication. If their bioavailability is increased, this communication and the state of homeostasis may be disrupted. With a pharmacometabonomic approach using NMR in combination with different chemometric methods, a determination was made of subtle changes in the metabo...Continue Reading

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Citations

Mar 14, 2020·Developmental Psychobiology·Amy L SalisburyPatricia A Brennan
Jun 5, 2018·International Journal of Toxicology·Melad G PaulisMohmed K M Aly
Aug 16, 2018·Scientific Reports·Francisco Adelvane de Paulo RodriguesAlexandre Havt

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