NMR exposure sensitizes tumor cells to apoptosis

Apoptosis : an International Journal on Programmed Cell Death
L GhibelliL M Porfiri

Abstract

NMR technology has dramatically contributed to the revolution of image diagnostic. NMR apparatuses use combinations of microwaves over a homogeneous strong (1 Tesla) static magnetic field. We had previously shown that low intensity (0.3-66 mT) static magnetic fields deeply affect apoptosis in a Ca2+ dependent fashion (Fanelli et al., 1999 FASEBJ., 13;95-102). The rationale of the present study is to examine whether exposure to the static magnetic fields of NMR can affect apoptosis induced on reporter tumor cells of haematopoietic origin. The impressive result was the strong increase (1.8-2.5 fold) of damage-induced apoptosis by NMR. This potentiation is due to cytosolic Ca2+ overload consequent to NMR-promoted Ca2+ influx, since it is prevented by intracellular (BAPTA-AM) and extracellular (EGTA) Ca2+ chelation or by inhibition of plasma membrane L-type Ca2+ channels. Three-days follow up of treated cultures shows that NMR decrease long term cell survival, thus increasing the efficiency of cytocidal treatments. Importantly, mononuclear white blood cells are not sensitised to apoptosis by NMR, showing that NMR may increase the differential cytotoxicity of antitumor drugs on tumor vs normal cells. This strong, differential potent...Continue Reading

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Citations

Mar 26, 2010·Apoptosis : an International Journal on Programmed Cell Death·Luciana Dini
Mar 20, 2010·International Journal of Cell Biology·Claudia CerellaLina Ghibelli
Sep 28, 2007·Apoptosis : an International Journal on Programmed Cell Death·Claudia CerellaLina Ghibelli
Jul 8, 2008·Molecular Aspects of Medicine·Shelly C Lu
Sep 3, 2009·Annals of the New York Academy of Sciences·Milena De NicolaLina Ghibelli
Mar 27, 2007·Annals of the New York Academy of Sciences·S NuccitelliL Ghibelli
Sep 13, 2013·BioMed Research International·Soumaya GhodbaneHafedh Abdelmelek
Nov 26, 2010·The International Journal of Biochemistry & Cell Biology·Claudia CerellaLina Ghibelli
Feb 17, 2006·European Journal of Pharmacology·Sung Hee LeeDong Hwan Sohn
Apr 6, 2018·Electromagnetic Biology and Medicine·Xiaofei TianXin Zhang
Aug 4, 2018·Environmental Science and Pollution Research International·Dongmei WangXin Zhang
Dec 20, 2015·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Ka-Eun KimIl-Young Cho

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