NMR spectroscopic analysis of neferine and isoliensinine

Magnetic Resonance in Chemistry : MRC
Jian Yang, Kailan Zhou

Abstract

Neferine and isoliensinine are the two major compositions of the Chinese medicine lotus plumule. They have extensive cardiovascular activity, such as antiarrhythmic, antithrombic and antihypertensive. In order to confirm the structures reported in the literature by explicit 1H and 13C assignments, we used a series of NMR experiments including 1H, 1H-COSY, HSQC and HMBC. The absolute configuration of neferine (C-1 and C-1') was determined as R and S and that of isoliensinine (C-1 and C-1') was determined as R and R.

Citations

Jun 3, 2006·Natural Product Reports·Kenneth W Bentley
Jun 17, 2009·Journal of Ethnopharmacology·Yang PanLong Chen
Mar 19, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Paramasivan PoornimaViswanadha Vijaya Padma
Oct 11, 2014·Archives of Pharmacal Research·Hyun Ah JungJae Sue Choi
Nov 25, 2004·Magnetic Resonance in Chemistry : MRC·Jian Yang
Mar 8, 2020·BMC Complementary Medicine and Therapies·Jingjing ChenShao Liu
Oct 20, 2021·Chemistry & Biodiversity·Tuan-Wu CaoXian-Wen Yang

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