PMID: 9173896Apr 1, 1997Paper

NMR study of the galactomannans of Trichophyton mentagrophytes and Trichophyton rubrum

The Biochemical Journal
K IkutaY Okawa

Abstract

Around 90% of chronic dermatophyte infections are caused by the fungi Trichophyton mentagrophytes and Trichophyton rubrum. One of the causes of the chronic infection resides in the immunosuppressive effects of the cell-wall components of these organisms. Therefore we have attempted to identify the chemical structure of galactomannan, one of the major cell-wall components. The cell-wall polysaccharides secreted by T. mentagrophytes and T. rubrum were isolated from the culture medium and fractionated into three subfractions by DEAE-Sephadex chromatography. Analysis of each subfraction by NMR indicated that there are two kinds of polysaccharides present, i.e. mannan and galactomannan. The mannan has a linear backbone consisting of alpha1,6-linked mannose units, with alpha1,2-linked mannose units as side chains. The core mannan moiety of the galactomannan was analysed by a sequential NMR assignment method after removing the galactofuranose units by acid treatment. The result indicates that the mannan moiety has a linear repeating structure of alpha1,2-linked mannotetraose units connected by an alpha1,6 linkage. The H-1 signals of the two intermediary alpha1, 2-linked mannoses of the tetraose unit showed a significant upfield shift ...Continue Reading

Citations

Nov 19, 2005·Microbes and Infection·M R M CamposS R Almeida
May 25, 2010·FEMS Microbiology Reviews·Juan Antonio LealDavid L Hawksworth
May 31, 2016·International Journal of Medical Microbiology : IJMM·Annegret WiedemannFrank Ebel
Jul 21, 2010·Natural Product Research·Bahar AhmedAdnan J Al-Rehaily
Feb 5, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Cristiane Beatriz de OliveiraPaulo Ricardo Criado
Jun 30, 2018·Experimental Dermatology·Émilie FawayYves Poumay
May 15, 2008·Mycopathologia·Sandy VermoutBernard Mignon
Oct 6, 2005·The Journal of Biological Chemistry·Corina CostachelThierry Fontaine
Oct 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin-Sung ChungKiyoshi Ariizumi
Oct 7, 1997·FEBS Letters·K IkutaY Okawa
Sep 9, 2017·Future Science OA·Carla MarinoRosa M de Lederkremer
Jul 11, 2001·FEMS Microbiology Letters·G L WallisJ F Peberdy
Aug 19, 2010·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Yumi Shiraki Ogawa
Jun 28, 2017·The Journal of Biological Chemistry·Hadar FeinbergMaureen E Taylor
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May 4, 2013·Journal of Agricultural and Food Chemistry·Phuong Dinh KimOlga Valentová
Jun 6, 2013·Journal of Natural Products·Samuel BertrandJean-Luc Wolfender

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