N,N,-diethyl-m-toluamide (DEET) suppresses humoral immunological function in B6C3F1 mice

Toxicological Sciences : an Official Journal of the Society of Toxicology
D E KeilM M Peden-Adams

Abstract

N,N-diethyl-meta-toluamide (DEET) is a particularly effective broad-spectrum insect repellent used commonly in recreational, occupational and military environments. Due to its widespread use and suggested link to Gulf War Illness, this study examined the immunotoxicity of DEET. Adult female B6C3F1 mice were injected sc for 14 days with DEET at 0, 7.7, 15.5, 31, or 62 mg/kg/day. Due to differences in the dermal absorption of DEET between mice and humans, this study eliminated this confounding factor by utilizing sc injection and measured circulating blood levels of DEET to assess bioavailability from sc administration. Effects on lymphocyte proliferation, natural killer cell activity, thymus and spleen weight and cellularity, the antibody plaque-forming cell (PFC) response, and thymic and splenic CD4/CD8 lymphocyte subpopulations were assessed 24 h after the last dose. No effect was observed in lymphocyte proliferation, natural killer cell activity, thymic weight, splenic weight, thymic cellularity, or splenic cellularity. Significant decreases were observed in the percentage of splenic CD4-/CD8- and CD4+/CD8- lymphocytes but only at the 62 mg DEET/kg/day treatment level and not in absolute numbers of these cells types. Addition...Continue Reading

References

Jun 1, 1979·The Journal of Investigative Dermatology·T S SpencerH I Maibach
Jul 1, 1979·The Journal of Pediatrics·C M Zadikoff
Feb 11, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterG J Rosenthal
Jan 21, 1992·Journal of Immunological Methods·J BryantR B Herberman
Jun 1, 1991·Journal of Pharmaceutical Sciences·W G ReifenrathM S Kurtz
Jan 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterJ H Dean
Jan 1, 1986·Journal of Toxicology and Environmental Health·P J Robbins, M G Cherniack
Apr 1, 1985·Journal of Leukocyte Biology·S S DukeM P Holsapple
May 1, 1970·The Journal of Investigative Dermatology·R J Feldmann, H I Maibach
Apr 18, 1966·JAMA : the Journal of the American Medical Association·I H Gilbert
Sep 1, 1982·Journal of Pharmaceutical Sciences·W G Reifenrath, P B Robinson
Apr 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S SelimG P Schoenig
Jan 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M K SelgradeM I Luster
Oct 1, 1994·Journal of the American Dietetic Association
Oct 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G P SchoenigC V Vorhees
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterW Craig
Dec 1, 1995·Toxicology Letters·F J BaudC Bismuth
Dec 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M B Abou-DoniaT L Kurt
Jan 15, 1997·JAMA : the Journal of the American Medical Association·R W Haley, T L Kurt
Feb 7, 1997·Journal of Toxicology and Environmental Health·W C McCainG Leach
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·T G Osimitz, J V Murphy
Feb 27, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·G P SchoenigE I Goldenthal
Aug 14, 1999·International Journal of Cancer. Journal International Du Cancer·W J Wu, S B Pruett
Jan 25, 2000·Cleveland Clinic Journal of Medicine·S D Frost
Jul 25, 2000·European Journal of Clinical Investigation·P M SoetekouwJ W van der Meer
Jan 10, 2002·Environmental Health Perspectives·Harvey J ClewellHugh A Barton
Oct 12, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dana B BarrLarry L Needham
Feb 9, 1961·The New England Journal of Medicine·J GRYBOSKIN K ORDWAY
Dec 18, 2003·Journal of Toxicology. Clinical Toxicology·Daniel L Sudakin, Wade R Trevathan
Jun 4, 2004·Environmental Health Perspectives·Aristo Vojdani, Jack D Thrasher
Oct 28, 2006·Journal of the American Mosquito Control Association·Douglas B Carlson
May 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauJennifer Seed
Jun 15, 2007·Journal of Toxicology and Environmental Health. Part a·Margie M Peden-AdamsDeborah E Keil
Apr 26, 1963·Science·N K Jerne, A A Nordin

❮ Previous
Next ❯

Citations

Jan 9, 2013·Medical Microbiology and Immunology·Ayaid Khadem Zgair
Sep 13, 2012·Journal of Immunotoxicology·Koichi HayashiTadashi Kosaka
Feb 9, 2017·Environmental Toxicology and Pharmacology·Dijendra Nath RoyAyantika Pal
Nov 24, 2011·Toxicologic Pathology·Jamie C DeWittRodney R Dietert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.