No acute effects of an exposure to 50 ppm acetaldehyde on the upper airways.

International Archives of Occupational and Environmental Health
Axel MuttrayS Letzel

Abstract

German MAK value of acetaldehyde has been fixed at 50 ppm to prevent from irritating effects. The threshold value is mainly based on animal experiments. The aim of this study was to evaluate acute effects of an exposure to 50 ppm acetaldehyde on the upper airways of human subjects. Twenty subjects were exposed to 50 ppm acetaldehyde and to air in an exposure chamber for 4 h according to a crossover design. Subjective symptoms were assessed by questionnaire. Olfactory threshold for n-butanol and mucociliary transport time were measured before and after exposure. Concentrations of interleukin 1beta and interleukin 8 were determined in nasal secretions taken after exposure. mRNA levels of interleukins 1beta, 6 and 8, tumour necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1, and cyclooxygenases 1 and 2 were measured in nasal epithelial cells, gained after exposure. Possible effects were investigated by semiparametric and parametric crossover analyses. Exposure to acetaldehyde did not cause any subjective irritating symptoms. Olfactory threshold did not change. Mucociliary transport time increased insignificantly after exposure to acetaldehyde. Neither concentrations of interleuk...Continue Reading

References

Jan 1, 1991·Pulmonary Pharmacology·J N Baraniuk
May 18, 1989·Nature·S Kwok, R Higuchi
Oct 1, 1994·Alcoholism, Clinical and Experimental Research·J H Sisson, D J Tuma
Oct 1, 1995·The Annals of Occupational Hygiene·B JärvholmC Peterson
Jul 1, 1996·The Journal of Allergy and Clinical Immunology·D Diaz-SanchezA Saxon
Jan 1, 1996·Advances in Immunology·W L Smith, D L Dewitt
Oct 29, 1999·International Archives of Occupational and Environmental Health·A MuttrayJ Konietzko
Mar 8, 2000·The European Respiratory Journal·F Sánchez-TorilJ Marín
Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·T A WyattJ H Sisson
Nov 9, 2000·American Journal of Rhinology·R Eccles
Apr 17, 2002·International Archives of Occupational and Environmental Health·A MuttrayC Kreiner
Jul 20, 2002·The Annals of Otology, Rhinology, and Laryngology·Wolf J MannJohannes Konietzko
Dec 14, 1957·Journal of the American Medical Association·V M SIM, R E PATTLE
Jul 31, 2004·BioTechniques·Keertan DhedaAlimuddin Zumla
Oct 30, 2004·Acta Oto-laryngologica·Sari KoskinenHely Tuorila
Nov 19, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·J B MorrisD J Shusterman
Aug 2, 2005·Alcohol·Philip J Brooks, Jacob A Theruvathu
Jan 26, 2006·International Archives of Occupational and Environmental Health·Fabriziomaria Gobba
Mar 18, 2006·The Journal of Hospital Infection·J-U S JensenL P Andersen
Jul 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ryan P VaughanJohn B Morris
Oct 6, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T HummelA Mackay-Sim
Jun 27, 2007·Novartis Foundation Symposium·Richard A DeitrichVasilis Vasiliou
Sep 1, 2007·Chemical Senses·Jörn LötschThomas Hummel
Oct 19, 2007·Regulatory Toxicology and Pharmacology : RTP·Isabelle LangGerhard Triebig

❮ Previous
Next ❯

Citations

Sep 4, 2014·Archives of Toxicology·Thomas BrüningChristoph van Thriel
Feb 9, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Varsha HandeManoor Prakash Hande
Jan 10, 2021·International Journal of Environmental Research and Public Health·Parham AzimiJoseph G Allen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.