No adaptation to UV-induced immunosuppression and DNA damage following exposure of mice to chronic UV-exposure

Journal of Photochemistry and Photobiology. B, Biology
P A SteerenbergH Van Loveren

Abstract

It is well known that ultraviolet (UV) radiation induces erythema, immunosuppression and carcinogenesis. We hypothesized that chronic exposure to solar UV radiation induces adaptation that eventually prevents the suppression of acquired immunity. We studied adaptation for UV-induced immunosuppression after chronic exposure of mice to a suberythemal dose of solar simulated radiation (SSR) with Cleo Natural lamps, and subsequent exposure to an immunosuppressive dose of solar or UVB radiation (TL12). After UV dosing, the mice were sensitized and challenged with either diphenylcyclopropenone (DPCP) or picryl chloride (PCl). To assess the adaptation induced by solar simulated radiation, we measured the proliferative response and cytokine production of skin-draining lymph node cells after immunization to DPCP, the contact hypersensitivity (CHS) response to PCl, and thymine-thymine (T-T) cyclobutane dimers in the skin of mice. After induction of immunosuppression by SSR or by TL12 lamps, the proliferative response of draining lymph node cells after challenge with DPCP, or the CHS after challenge with PCl, showed significant suppression of the immune response. Chronic irradiation from SSR preceding the immunosuppressive dose of UV fail...Continue Reading

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Citations

Jan 5, 2008·Photochemistry and Photobiology·Mary NorvalJoanna Narbutt
May 28, 2013·Journal of Photochemistry and Photobiology. B, Biology·Soumik GoswamiChandana Haldar
Mar 17, 2017·PloS One·Marie-Catherine Drigeard DesgarnierPatrick J Rochette
Oct 5, 2021·Journal of Forensic Sciences·Weitao YanJifeng Cai

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