No additional protection against ventriculitis with prolonged systemic antibiotic prophylaxis for patients treated with antibiotic-coated external ventricular drains

Journal of Neurosurgery
Rory K J MurphyGregory J Zipfel

Abstract

OBJECT External ventricular drains (EVDs) are commonly used for CSF diversion but pose a risk of ventriculitis, with rates varying in frequency from 2% to 45%. Results of studies examining the utility of prolonged systemic antibiotic therapy for the prevention of EVD-related infection have been contradictory, and no study to date has examined whether this approach confers additional benefit in preventing ventriculitis when used in conjunction with antibiotic-coated EVDs (ac-EVDs). METHODS A prospective performance analysis was conducted over 4 years to examine the impact of discontinuing systemic antibiotic prophylaxis after insertion of an ac-EVD on rates of catheter-related ventriculitis. Ventriculitis and other nosocomial infections were ascertained by a qualified infection disease nurse using definitions based on published standards from the Centers for Disease Control and Prevention, comparing the period when patients received systemic antibiotic therapy for the duration of EVD treatment (Period 1) compared with only for the peri-insertion period (Period 2). Costs were analyzed and compared across the 2 time periods. RESULTS Over the 4-year study period, 866 patients were treated with ac-EVDs for a total of 7016 catheter d...Continue Reading

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Citations

Jun 4, 2016·Journal of Neurosurgery·Ariane LewisDonato Pacione
Feb 17, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelJoseph R Zunt
Oct 27, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Aimun A B JamjoomUNKNOWN British Neurosurgical Trainee Research Collaborative
Nov 3, 2017·British Journal of Neurosurgery·Ariane LewisDonato Pacione
Jan 30, 2020·Expert Review of Anti-infective Therapy·Kirsten R I S DorresteijnDiederik van de Beek
Dec 17, 2019·Anesthesiology·Brooke K DeckerNaomi P O'Grady
Sep 25, 2018·Neurology Research International·Stephen AlbanoMudassir Farooqui
Jul 13, 2018·Neurocritical Care·Aaron Sylvan LordAriane Lewis
Jan 12, 2021·Acta neurochirurgica·Bujung HongJoachim K Krauss
Nov 13, 2020·Chinese Medical Journal·Yong-Gang GuiChen-Guang Zhao

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