No apparent difference in the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the sympathetic system in NMRI and C57 BL/6 mice

Toxicology Letters
J Luthman, E Sundström

Abstract

The parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to possess marked species as well as strain differences in toxicity on central catecholaminergic systems. In the present study the effects on the peripheral sympathetic nervous system following treatment with MPTP, as well as its metabolite 1-methyl-4-phenylpyridine (MPP+) and the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) were studied in mice of the NMRI and C57 BL/6 strains, two strains that possess marked difference in MPTP toxicity on central catecholaminergic neurons. No strain differences in the depletions of noradrenaline (NA) in iris and heart auricula and of NA and dopamine (DA) in superior cervical ganglion or in the reduction of the in vitro [3H]NA uptake in iris or heart auricula were found following MPTP treatment (2 X 40 mg/kg s.c., 2 and 7 days). Treatment with the NA uptake blocker desipramine (DMI) did not affect the MPTP-induced NA depletion in either strain. Following treatment with MPP+ (30 mg/kg i.v., 7 days) no differences in the two strains were seen on the reduction of NA levels in iris and heart auricula or decrease in [3H]NA uptake. In addition, no differences were found on NA levels in iris...Continue Reading

References

Oct 7, 1986·European Journal of Pharmacology·P K Sonsalla, R E Heikkila
Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer

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Citations

Oct 30, 2001·Behavioural Brain Research·M SedelisJ P Huston
Jan 19, 2010·Neurobiology of Disease·Marifé Cano-JaimezIsabel Fariñas
Dec 1, 2004·Journal of Neurochemistry·Karen S RommelfangerGary W Miller
Jun 14, 2003·The Journal of Pharmacology and Experimental Therapeutics·David S GoldsteinKrys Bankiewicz
Jan 4, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jeanette M Metzger, Marina E Emborg
Oct 19, 2004·Journal of Neuroscience Methods·Marina E Emborg
Oct 8, 2021·Scientific Reports·Lorena Cuenca-BermejoMaría-Trinidad Herrero

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