No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies

Neuroreport
Andrew B SingletonC M Morris

Abstract

The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical and pathological overlaps between AD and dementia with Lewy bodies we genotyped 46 pathologically confirmed cases of dementia with Lewy bodies for the PS-1 polymorphism and compared the allelic frequencies with 87 age-matched control cases and 103 age-matched AD cases. No association between dementia with Lewy bodies and PS-1 allele 1 was found either in the group as a whole, or in the group stratified according to dosage of the epsilon4 allele of the apolipoprotein E gene. We suggest that either the presenilin polymorphism has no effect on dementia with Lewy bodies or that any linkage is precluded by another, more influential, locus.

References

May 1, 1993·Journal of Neuropathology and Experimental Neurology·M S PollanenC Bergeron

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Citations

Jul 25, 2000·Psychiatry Research·K OharaK Ohara
Mar 25, 2004·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Richard Camicioli, Nancy Fisher
Aug 17, 2004·Neuroscience Letters·Paola LucarelliPaolo Curatolo
Jan 4, 2020·International Journal of Geriatric Psychiatry·Hazel SanghviAnto P Rajkumar
Apr 18, 1998·Brain Pathology·P G InceC M Morris

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