No association between alcohol consumption and risk of atrial fibrillation: A two-sample Mendelian randomization study

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Qi JiangMinglong Chen

Abstract

Although many observational studies have suggested that alcohol intake was associated with incident atrial fibrillation (AF), controversy remains. This study aimed to examine the causal association of alcohol intake with the risk of AF. Two-sample Mendelian randomization (MR) analysis was performed to estimate the causal effects of alcohol consumption, alcohol dependence, or alcohol use disorder identification test (AUDIT) scores on AF. Summary data on single nucleotide polymorphisms (SNPs) associated with AF were obtained from a genome-wide association study (GWAS) with up to 1,030,836 participants. The fixed- and random-effect inverse-variance weighted (IVW) methods were used to calculate the overall causal effects. MR analysis revealed nonsignificant association of genetically predicted alcohol consumption with risk of AF using fixed- and random-effect IVW approaches (odds ratio (OR) [95% confidence interval (CI)] = 1.004 [0.796-1.266], P = 0.975; OR [95% CI] = 1.004 [0.766-1.315], P = 0.979). Genetically predicted alcohol dependence was also not causally associated with AF in the fixed- and random-effect IVW analyses (OR [95% CI] = 1.012 [0.978-1.048], P = 0.490; OR [95% CI] = 1.012 [0.991-1.034], P = 0.260). There was no s...Continue Reading

Citations

Mar 26, 2021·Trends in Cardiovascular Medicine·Theodora A ManolisAntonis S Manolis
Apr 17, 2021·Future Cardiology·Rea MittalRohit Jain
Aug 23, 2021·European Journal of Epidemiology·Inge A T van de LuitgaardenJoline W J Beulens

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