No association between FTO or HHEX and endometrial cancer risk.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Mia M GaudetMontserrat Garcia-Closas

Abstract

Obesity and diabetes are known risk factors for endometrial cancer; thus, the genetic risk factors of these phenotypes might also be associated with endometrial cancer risk. To evaluate this hypothesis, we genotyped tag-single nucleotide polymorphisms (SNP) and candidate SNPs in FTO and HHEX in a primary set of 417 endometrial cancer cases and 406 population-based controls, and validated significant findings in a replication set of approximately 2,347 cases and 3,140 controls from three additional studies. We genotyped 189 tagSNPs in FTO (including rs8050136) and five tagSNPs in HHEX (including rs1111875) in the primary set and one SNP each in FTO (rs12927155) and HHEX (rs1111875) in the validation set. Per allele odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the association between the genotypes of each SNPs (as an ordinal variable) and endometrial cancer risk using unconditional logistic regression models, controlling for age and site. In the primary study, the most significant finding in FTO was rs12927155 (OR, 1.56; 95% CI, 1.21-2.01; P = 5.8 x 10(-4)), and in HHEX, it was rs1111875 (OR, 0.80; 95% CI, 0.66-0.97; P = 0.026). In the validation studies, the pooled per allele OR, adjusted for ag...Continue Reading

References

May 10, 2007·Genetic Epidemiology·Zhaoxia Yu, Daniel J Schaid
Jan 4, 2008·Human Genetics·Mia M GaudetMontserrat Garcia-Closas
Feb 1, 2008·Gynecologic Oncology·Amanda SpurdleUNKNOWN Australian National Endometrial Cancer Study

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Citations

Mar 8, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guiqiong LiZhongming Yuan
Nov 20, 2013·Nature Reviews. Endocrinology·Ruth J F Loos, Giles S H Yeo
Jul 27, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Tracy A O'MaraAmanda B Spurdle
Jan 29, 2014·Diabetes Research and Clinical Practice·R C W MaJ C Chan
Mar 5, 2016·European Journal of Cancer Care·Xiaoyi HuangJianming Zheng
Nov 26, 2015·PloS One·Jennifer PrescottImmaculata De Vivo
Jun 27, 2017·Genetic Testing and Molecular Biomarkers·Yaser MansooriFarzaneh Darbeheshti
Nov 13, 2014·Molecular Biology Reports·Marta Elena Hernández-Caballero, José Alfredo Sierra-Ramírez
Jan 28, 2021·Pharmacogenomics and Personalized Medicine·Yuxiang LiaoJie Zhao
Oct 1, 2021·Oncology Letters·Yang ZhouWeigan Shen

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