PMID: 8609452Feb 1, 1996Paper

No association between p53 status and alpha-particle-induced chromosomal instability in human lymphoblastoid cells

International Journal of Radiation Biology
M A KadhimE G Wright

Abstract

Previous work has demonstrated that alpha-particle irradiation of primary human bone marrow cells leads to the transmission of chromosomal instability in the descendants of the irradiated cell, although there is some interindividual variation. We have extended these studies to human EBV-transformed lymphoblastoid cell lines in order to establish an in vitro model system. The five cell lines analyzed, including one from a Fanconi anaemia patient, exhibited high levels of persistent chromatid aberrations up to approximately 40 cell generations after alpha-irradiation. The p53 status of the cell lines was defined according to whether cellular p53 levels were induced by irradiation, translocated to the nucleus and were able to bind a p53 DNA consensus recognition sequence in vitro. Together with the primary bone marrow cell studies, we conclude that alpha-particle induced chromosomal instability is independent of the p53 status of the cell as defined in these studies.

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Citations

May 15, 2004·Molecular and Cellular Biology·Lei HuangWilliam F Morgan
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·S A LorimoreE G Wright
Feb 26, 2004·Radiation Research·Carmel MothersillC B Seymour
Sep 12, 2007·International Journal of Health Services : Planning, Administration, Evaluation·Rosalie BertellInge Schmitz-Feuerhake
Oct 15, 2003·Oncogene·Keiji SuzukiMasami Watanabe
Oct 15, 2003·Oncogene·Munira A Kadhim
Jan 6, 1999·The Journal of Pathology·N C KerrM A Plumb
Jul 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Ajay MalviyaElizabeth A Lingard
Jul 11, 2003·Health Physics·Leslie E SmithWilliam F Morgan
Jul 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Bobby R ScottVernon E Walker
May 4, 2006·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·M S Bhamra, C P Case

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