No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase

Biochemical and Biophysical Research Communications
F HodaD A Collier

Abstract

Idiopathic Parkinson's disease (IPD) is characterised by the loss of pigmented neurones in the substantia nigra, leading to reduced tyrosine hydroxylase activity and depletion of dopamine. Treatments attempt to correct this deficit by the use of levodopa and inhibitors of dopamine metabolising enzymes such as catechol-O-methytransferase (COMT). A common amino-acid polymorphism in COMT, valine-108-methionine, results in a low activity form of the enzyme which we hypothesised may influence susceptibility to IPD. We examined this polymorphism in 139 Caucasian subjects with IPD and 173 control subjects, using a PCR-RFLP and a novel Amplification Refractory Mutation System (ARMS) assay. Allele and genotype frequencies were similar in the affected and control subjects, indicating that variation of COMT activity is not an aetiological factor in IPD. We have also characterised a new polymorphism, 256C/G, which is not associated with IPD. However it remains possible that allelic variation in COMT influences severity, type of pathology or treatment response to levodopa or COMT inhibitors.

Citations

Feb 15, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Stephan KlebeUNKNOWN International Parkinson's Disease Genomics Consortium (IPDGC)
Jul 26, 2011·BMC Neurology·Chikako KiyoharaUNKNOWN Fukuoka Kinki Parkinson's Disease Study Group
Jul 1, 1998·Environmental Health Perspectives·M A Rossing
Sep 1, 2009·Journal of Substance Abuse Treatment·Bradley T ConnerErnest P Noble
Jun 30, 2006·Journal of Neurochemistry·Liat Benmoyal-Segal, Hermona Soreq
Nov 5, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Weidong JiLanting Guo
Jul 26, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lixue ChuanXianyu Zhang
Jan 7, 1999·Journal of Geriatric Psychiatry and Neurology·H Payami, S Zareparsi
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·I MizutaC Tanaka
Jan 14, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·K R ChaudhuriD J Brooks
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Monique SaintotMariette Gerber
Dec 19, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M GabrovsekD A Collier
Jul 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tao LiDavid A Collier
Jun 20, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·David R LynchAndrew D Siderowf
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·John L GoudreauWalter A Rocca
Jan 1, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tao LiDavid A Collier
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·A G RiedlC D Marsden
Jan 18, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·E BramonR M Murray
Mar 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·D C WanC P Pang
Mar 19, 2016·Acta Neurologica Scandinavica·H TakigawaK Nakashima
Apr 18, 1998·Brain Pathology·P G InceC M Morris
Nov 11, 1998·Journal of the American Geriatrics Society·E Gómez-TortosaB T Hyman
Jan 3, 2001·European Journal of Pharmacology·T ArinamiE S Onaivi

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