PMID: 9184311May 31, 1997Paper

No association between polymorphisms in the human dopamine D3 and D4 receptors genes and alcoholism

American Journal of Medical Genetics
A ParsianC R Cloninger

Abstract

The human dopamine D2 receptor gene (DRD2) has received considerable attention for the past several years as a potential candidate that may affect susceptibility to alcoholism. The association studies that compared the frequencies of alleles of DRD2 gene between alcoholics and control groups have produced equivocal results. Dopamine D3 and D4 receptor genes (DRD3 and DRD4) are in the same class as DRD2 but with different pharmacological properties. We have used relative risk and haplotype relative risk approaches to test associations between alleles of DRD3 and DRD4 genes and alcoholism. For relative risk studies 162 probands from multiple incidence alcoholic families have been compared to 89 psychiatrically normal controls. Haplotype relative risk approaches have used 29 alcoholic probands in which both parents were available for genotyping. The Bal I restriction enzyme site in DRD3 and tandem repeat (VNTR) in DRD4 genes polymorphisms were used to genotype the above samples. The results of relative risk approaches for both DRD3 and DRD4 genes were negative for comparisons of alcoholics and subtypes of alcoholics with normal controls. Haplotype relative risk approaches also were negative for both genes. These results suggest th...Continue Reading

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Citations

Jul 2, 2014·Acta Neuropsychiatrica·Lakkakula V K S Bhaskar, Shanmugasundaram Arun Kumar
Apr 25, 2000·Alcoholism, Clinical and Experimental Research·H IshiguroT Arinami
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