No association between serotonin 5-HT 1A receptors and spirituality among patients with major depressive disorders or healthy volunteers

Molecular Psychiatry
H KarlssonJ Hietala

Abstract

An earlier study (Borg et al., Am J Psychiatry 2003) found an inverse correlation between [carbonyl-(11)C]WAY-100635 ligand binding to 5-HT(1A) receptors and scores for self-transcendence, but no other of the six dimensions of the Temperament and Character Inventory, in a group of healthy males. The aim of this study was to investigate if the finding of an inverse correlation between spirituality and 5-HT(1A) could be seen in patients suffering from major depressive disorder or replicated among healthy volunteers. A total of 23 patients with major depressive disorder and 20 healthy volunteers were examined with PET using [carbonyl-(11)C]WAY-100635 as the radioligand. The personality traits were measured using the Finnish version of the Temperament and Character Inventory and correlated with ligand binding (BP). No significant correlations were found between the different Temperament and Character Inventory subscales and BP in any of the studied brain regions (amygdala, anterior cingulate cortex, dorsal raphe nuclei, dorsolateral prefrontal cortex, angular gyrus, inferior, middle, and superior temporal gyri, medial prefrontal cortex orbitofrontal cortex, hippocampus, insular cortex, subgenual anterior cingulate cortex, supramarg...Continue Reading

References

Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Jun 2, 1998·Comprehensive Psychiatry·S BrändströmR Adolfsson
Mar 27, 1999·Journal of Psychiatric Research·M HansenneM Ansseau
Sep 10, 1999·Twin Research : the Official Journal of the International Society for Twin Studies·M E McCullough, D B Larson
Nov 5, 2003·The American Journal of Psychiatry·Jacqueline BorgLars Farde
May 24, 2005·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Sian CottonSusan L Rosenthal
May 11, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jussi HirvonenJarmo Hietala
Dec 5, 2006·Archives of Women's Mental Health·A JosefssonP-O Nylander
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Oct 9, 2007·Nuclear Medicine and Biology·Wayne C DrevetsChester Mathis

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Citations

Sep 5, 2015·Psychiatry Research·Jussi HirvonenJarmo Hietala
Jan 12, 2019·Human Brain Mapping·Dea Siggaard StenbaekPatrick MacDonald Fisher
Apr 9, 2019·Expert Opinion on Pharmacotherapy·Andreas FontalisEleftherios Tsiridis
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lars FardeSimon Cervenka
Dec 15, 2020·Frontiers in Psychology·Alexandra KitsonBernhard E Riecke

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