No association between serum levels of insulin-like growth factor-I, vascular endothelial growth factor, prolactin and clinicopathological characteristics of breast carcinoma after surgery

Internal Medicine Journal
B SancakSecil Ozkan

Abstract

Angiogenesis is essential for tumour growth and metastasis. Vascular endothelial growth factor (VEGF) has been suggested as the major angio-genic factor in breast carcinoma. Both insulin-like growth factor-I (IGF-I) and prolactin are involved in the progression of breast cancer at least partly by stimulating angiogenesis. The aim of the present study was to investigate the association between serum IGF-I, VEGF and prolactin levels and clinicopathological characteristics of breast carcinoma. Serum IGF-I, VEGF and prolactin levels were measured in breast cancer patients and controls and these levels were compared with well-known clinicopathological characteristics of breast carcinoma, including tumour size, axillary lymph node and oestrogen/progesterone receptor status, tumour grade and disease stage. Serum prolactin, VEGF and IGF-I levels were found to be similar in breast cancer patients and control subjects (P > 0.05). When the patients were divided into groups according to their tumour size, axillary lymph node status, tumour grade, oestrogen/progesterone receptor status and disease stage, no significant differences in serum prolactin, VEGF and IGF-I levels were found among the groups (P > 0.05). The present study failed to d...Continue Reading

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Citations

Mar 16, 2006·Breast Cancer Research and Treatment·Lukas A HeflerRobert Zeillinger
Jan 22, 2008·Journal of Mammary Gland Biology and Neoplasia·Carmen ClappGonzalo Martínez de la Escalera
Jan 10, 2006·Cancer Biotherapy & Radiopharmaceuticals·Jen-Der Lin, Tzu-Chieh Chao
Oct 21, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kalliopi Pazaitou-PanayiotouChristos S Mantzoros
Apr 23, 2005·Internal Medicine Journal·S FerreroN Ragni
Jul 1, 2005·Breast Cancer Research : BCR·Mary-Ann PollmannMartin Sandig
Sep 30, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Aneta CymbalukIzabella Rzepka-Górska
Oct 4, 2007·British Journal of Cancer·C KutA S Popel
Aug 10, 2004·World Journal of Gastroenterology : WJG·Xiu-Jie WangWen-Dong Wang

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