No association between the COMT Val158Met polymorphism and cognitive training response in healthy Shanghai community-dwelling elderly individuals.

Annals of Palliative Medicine
Wei FengChunbo Li

Abstract

Cognitive training may have an effect on promoting the maintenance of cognitive functions in healthy elderly adults. The catechol-O-methyltransferase (COMT) variant Val158Met (rs4680) is a wellstudied functional variant that has been associated with differences in cognitive functions. Whether this COMT polymorphism is associated with cognitive performance after training remains unknown. We tested whether the COMT Val158Met polymorphism could influence the cognitive function over time in healthy community-dwelling elderly adults who participated in a multi-domain cognitive training intervention. A total of 147 healthy Chinese individuals at 70 years of age and older who met the inclusion criteria were recruited from one urban community in Shanghai. One group (n=88) accepted multi-domain cognitive training over the span of 12 weeks. The control group (n=59) did not receive any intervention. Individuals underwent a multi-domain neuropsychological test four times over the course of a year (baseline, post-intervention, and 6-12 months follow-up). Composite measures of cognitive function were identified from neuropsychological test scores via factor analysis. Effects of the intervention and carrying the COMT Val158Met allele on cogni...Continue Reading

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