No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population

Neuroscience Letters
Wuyan ChenLin He

Abstract

The RTN4 gene on chromosome 2p13-14 has been reported to be over-expressed in schizophrenia by a cDNA subtractive hybridization experiment between postmortem human frontal cerebral cortices from Canadian schizophrenia individuals and neurological controls. The same study also reported a high prevalence of homozygous CAA insertion in the schizophrenia. In a replication attempt to investigate the role of RTN4 in the etiology of schizophrenia, we genotyped the CAA insertion polymorphism and other three genetic polymorphisms (a TATC deletion in the 3'-untranslated region and two single nucleotide polymorphisms in the 5' region) within RTN4 and conducted a case-control study in the Chinese population. There were no significant discrepancies in allele and genotype frequencies of the four polymorphisms individually and haplotype distribution between the cases and the controls. Our current data suggest that the genetic polymorphisms within RTN4 are unlikely to confer an increased susceptibility to schizophrenia in the Chinese population.

References

Sep 19, 1987·British Medical Journal·R M Murray, S W Lewis
Sep 9, 1995·Lancet·P McGuffinA E Farmer
Feb 10, 2000·Nature·R PrinjhaF S Walsh
May 9, 2000·Human Heredity·J H ZhaoP C Sham
Feb 15, 2001·American Journal of Human Genetics·M Baron
Jan 31, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S KumraR Augustin
Jun 8, 2002·Annual Review of Neuroscience·David A Lewis, Pat Levitt
Nov 12, 2002·Brain Research. Molecular Brain Research·G NovakT Tallerico
Dec 19, 2002·Journal of Molecular Biology·Thomas OertleMartin E Schwab
Apr 30, 2003·Neuron·Clifford J Woolf
Apr 30, 2003·Neuron·Ji Eun KimStephen M Strittmatter
Apr 30, 2003·Neuron·Binhai ZhengMarc Tessier-Lavigne
May 14, 2003·Archives of General Psychiatry·Kenneth L DavisVahram Haroutunian
Jun 13, 2003·American Journal of Human Genetics·Cathryn M LewisTomas Helgason
Aug 5, 2003·Nature Reviews. Genetics·Jeffrey D Wall, Jonathan K Pritchard
Nov 12, 2003·Molecular Psychiatry·E J C G van den Oord, B M Neale

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Citations

Jun 15, 2005·Brain Research. Molecular Brain Research·Ene-Choo TanYik-Ying Teo
Jan 21, 2011·Journal of Psychiatry & Neuroscience : JPN·Noah L LazarDonald P Cain
Oct 19, 2010·Progress in Neurobiology·Nagahide TakahashiJoseph D Buxbaum
Jul 14, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jing DuQinghe Xing
Oct 25, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bin ZhouLin Zhang
Mar 12, 2015·Psychiatry and Clinical Neurosciences·Chenyao WangNorio Ozaki

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