PMID: 11901357Mar 20, 2002Paper

No association for D2 and D4 dopamine receptor polymorphisms and methamphetamine abuse in Chinese males

Psychiatric Genetics
Shih-Jen TsaiChen-Jee Hong

Abstract

The D2 and D4 dopamine receptors (DRD2 and DRD4) play major roles in the central effects of psychostimulants and in the reward system. Previous studies, although not all, have demonstrated associations between the DRD2 TaqI and the DRD4 exon III variable number tandem repeat (VNTR) polymorphisms and substance dependence. For this study, we have investigated the associations between these two polymorphisms and methamphetamine (MAP) dependence, as manifested in a Chinese-male sample population. No significant difference was demonstrated for genotype or allele frequency when comparing MAP-dependent and control cases for the DRD2 TaqI and the DRD4 gene exon III VNTR polymorphisms, suggesting that these two polymorphisms do not play major roles in MAP dependence for our sample of Chinese males.

References

Dec 1, 1986·Archives of General Psychiatry·R J CadoretE Heywood
Dec 1, 1993·Human Molecular Genetics·D K GrandyO Civelli
Jan 9, 1993·Lancet·S ShaikhA Thornton
Oct 1, 1993·Drug and Alcohol Dependence·E P NobleM D Anglin
Aug 15, 1993·Biological Psychiatry·C L Barr, K K Kidd
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·L S SeidenG A Ricaurte
Jul 1, 1997·Molecular Psychiatry·M J OwenP McGuffin
Nov 18, 1998·Archives of General Psychiatry·K R MerikangasB J Rounsaville
Oct 19, 1999·Molecular Psychiatry·D E ComingsJ P MacMurray
Jul 6, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·E P Noble

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Citations

Feb 22, 2012·Human Genetics·Philip GorwoodMichel Simonneau
Apr 2, 2009·Pharmacology, Biochemistry, and Behavior·John McGeary
Mar 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hiroshi UjikeShigetoshi Kuroda
Feb 17, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chad A BousmanMing T Tsuang
Aug 20, 2005·Brain Research. Molecular Brain Research·Chih-Ya ChengShih-Jen Tsai
Dec 19, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Michelle LucianoN G Martin
Sep 14, 2007·CNS Drugs·Kevin P Hill, Mehmet Sofuoglu
Jan 31, 2009·Behavioural Pharmacology·Bernard Le FollPhilip Gorwood
Sep 27, 2018·International Journal of Environmental Research and Public Health·Jolanta ChmielowiecAnna Grzywacz
Nov 21, 2020·Neuroscience and Biobehavioral Reviews·Alexandre A GuerinJee Hyun Kim
Apr 14, 2021·Brain, Behavior and Evolution·F Scott HallFederico Resendiz-Gutierrez

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