No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene in Mexican patients and binary restenosis after coronary stenting

Clinica Chimica Acta; International Journal of Clinical Chemistry
Marco Antonio Martínez-RiosGilberto Vargas-Alarcón

Abstract

It has been suggested that the incidence of coronary restenosis after a percutaneous coronary intervention is much higher in patients with a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene (deletion allele) than in others, but published studies are conflicting. The presence (insertion) or absence (deletion) of a 287-bp alu repeat sequence within intron 16 of the ACE gene (I/D polymorphism) was analyzed by polymerase chain reaction in a group of 168 patients with coronary artery disease who underwent coronary artery stenting. Basal and procedure coronary angiographies were analyzed searching for angiographic predictors of restenosis and follow-up angiography was analyzed looking for binary restenosis. Distribution of angiotensin converting enzyme I/D polymorphisms was similar in patients with and without restenosis. Similar results were observed when the analysis was made considering the type of stent implanted. On the other hand, the whole group of coronary artery disease patients showed increased frequencies of the D allele (p=0.00001, OR=2.17, 95% CI=1.49-3.16) and ID genotype (p=0.0002, OR=2.58, 95%CI=1.49-4.47) when compared to healthy controls. Genetic variations of the ACE gen...Continue Reading

References

Jul 1, 1994·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·V J Dzau
Oct 1, 1993·PCR Methods and Applications·V ShanmugamB K Saha
Dec 1, 1993·Nature Genetics·M OhishiT Ogihara
Jan 13, 1999·Circulation·A FarbR Virmani
Jun 20, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·S J Wieczorek, G J Tsongalis
Jun 29, 2005·Circulation·Peter Libby, Pierre Theroux

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