No association of apolipoprotein epsilon 4 allele with schizophrenia even in cognitively impaired patients

Schizophrenia Research
F ThibautM Petit

Abstract

Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 (epsilon 4) with Alzheimer's disease or cognitive decline in elderly, we tested whether cognitive performance in schizophrenic subjects is associated with an increase in the frequency of the ApoE epsilon 4 allele. Our data indicate that in our sample: (1) there is no association between schizophrenia and the ApoE epsilon 4 allele; and (2) the ApoE epsilon 4 allele is not of major importance with regard to the cognitive decline observed in schizophrenia.

References

Aug 1, 1991·Perceptual and Motor Skills·D Boone
Aug 1, 1987·Journal of Clinical and Experimental Neuropsychology·G J Larrabee
Mar 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·P J Harrison
Jan 1, 1994·Alzheimer Disease and Associated Disorders·H M WisniewskiM Tarnawski
Nov 5, 1994·BMJ : British Medical Journal·E J FeskensD Kromhout
Jan 1, 1993·Schizophrenia Bulletin·I ProhovnikN Willson
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Apr 9, 1996·American Journal of Medical Genetics·R JooberC Benkelfat
Jun 1, 1996·Trends in Neurosciences·H S Soininen, P J Riekkinen
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·E JönssonG Sedvall
Jan 1, 1996·Psychiatric Genetics·S ZhuP Propping

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Citations

Sep 18, 2003·Biological Psychiatry·Brian DeanRalph N Martins
Aug 22, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·K NiizatoK Ikeda
Aug 2, 2001·Schizophrenia Research·S G Post
Jun 16, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Melanie Bilbul, Hyman M Schipper
Sep 16, 2015·Schizophrenia Research·Thelma Beatriz González-CastroMervyn Manuel Hernández-Alvarado
Jun 28, 2002·Acta Psychiatrica Scandinavica·P A SáizJ Bobes
Mar 29, 2006·Schizophrenia Research·Ming-Qing XuLin He
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Franck SchürhoffMarion Leboyer
Jun 13, 2017·Pharmacotherapy·Kristen M WardVicki L Ellingrod
May 8, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Daniel Martins-De-SouzaChristoph W Turck

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