No association of chromosome 9p21.3 variation with clinical and angiographic outcomes after placement of drug-eluting stents

JACC. Cardiovascular Interventions
Petra HoppmannWerner Koch

Abstract

After novel findings from genomewide association studies that sequence variation on chromosome 9p21.3 is a genetic factor for coronary heart disease, we investigated whether this locus influenced the clinical and angiographic outcomes after implantation of drug-eluting stents in coronary arteries. Recently, genomewide association studies have identified a locus on chromosome 9 (approximately 100 kb in band p21.3) as the strongest genetic factor for coronary heart disease. We studied the rs7865618, rs1537378, rs1333040, and rs1333049 polymorphisms located on chromosome 9p21.3 in a cohort of 2,028 patients who were treated with percutaneous coronary intervention and implantation of sirolimus- or paclitaxel-eluting stents. Records of 3-year adverse clinical outcomes were obtained from all stented patients. Follow-up angiography at 6 to 8 months after stenting was performed in 1,683 patients (83%). The polymorphisms were not significantly related with clinical outcomes at 3 years, including death (p >or= 0.18), myocardial infarction (p >or= 0.19), repeat revascularization (p >or= 0.08), and the composite end point of adverse events (death, myocardial infarction, repeat revascularization) (p >or= 0.34). No association of the polymor...Continue Reading

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Citations

Feb 23, 2010·JACC. Cardiovascular Interventions·Kalil G Abdullah
Feb 11, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Salim S ViraniChristie M Ballantyne
Jun 8, 2014·BMC Medical Genetics·Muhammad S MunirMohammad Hassan Murad
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