PMID: 8947330Nov 1, 1996Paper

No association of PROP taster status and paternal history of alcohol dependence

Alcoholism, Clinical and Experimental Research
H R KranzlerV M Hesselbrock

Abstract

Taste sensitivity to bitter substances, including ethanol, may play a moderating role both in the initiation of drinking and in the intensity and frequency of drinking once it is initiated. A study (Pelchat and Danowski, Physiol Behav 51:1261-1266, 1992) showed an association between the capacity to taste PROP (6-n-propylthiouracil), a bitter tasting compound, and a family history of alcoholism. The implication of that finding is that family-history-negative individuals may be protected from early initiation of drinking or heavy consumption of alcohol once drinking is initiated. The present study sought to replicate those findings by using direct interview methods (versus history methods) to obtain alcohol use and alcohol problem information from the parents of "at risk" individuals and by examining a larger number of subjects. A bimodal distribution of the ability to taste PROP was found, similar to that observed in the general population. No association was found between the ability to taste PROP and a paternal history of alcoholism, regardless of the taste threshold employed or after controlling for several potentially confounding variables. A lack of association with alcoholism risk was also observed for subjects' self-repo...Continue Reading

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Citations

Mar 10, 2001·Physiology & Behavior·R D Mattes, D DiMeglio
Nov 4, 1998·Drug and Alcohol Dependence·H R KranzlerV Modesto-Lowe
Aug 19, 2007·Chemical Senses·Theresa L WhiteSteven L Youngentob
Jun 14, 2013·Chemical Senses·Gregory SmutzerJames W Griffith
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Jen C WangAlison M Goate
Jul 28, 2004·Physiology & Behavior·Valerie B DuffyLinda M Bartoshuk
Oct 6, 2017·Critical Reviews in Food Science and Nutrition·Margaret Thibodeau, Gary J Pickering

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