No association of the hypoxia-inducible factor-1α gene polymorphisms with survival in patients with colorectal cancer.

Medical Oncology
Soo Jung LeeGyu Seog Choi

Abstract

Hypoxia-inducible factor-1 (HIF-1) is the key regulator of cellular response to hypoxia and presumably plays a central role in the control of tumor growth. The present study analyzed polymorphisms of HIF-1α gene and their impact on the prognosis for patients with colorectal cancer. Four hundred and forty-five consecutive patients with surgically resected colorectal adenocarcinoma were enrolled in the present study. The genomic DNA was extracted from fresh colorectal tissue, and 2 polymorphisms of HIF-1α gene (HIF-1α C1772T and HIF-1α G1790A) determined using a real-time PCR genotyping assay. The 2 HIF-1α gene polymorphisms were successfully amplified, and the frequencies of each genotype are as follows: [C1772T: CC (92.1%), CT (7.9%); G1790A: GG (93.0%), GA (7.0%)]. Survival analysis including stage, age, site of disease, and CEA level showed that these polymorphisms were not associated with survival. For the clinicopathologic parameters, CEA level and TNM stage were significant prognostic factors in a Cox model for survival. HIF-1α gene polymorphisms investigated in this study were not found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer. However, further studies are warra...Continue Reading

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Citations

Jun 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yi ZhangQi-Chao Huang
Jul 17, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin HuChao You
Nov 29, 2017·Oncotarget·Fuhao QiaoShihe Shao

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