No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk

Schizophrenia Research
M VergaE Smeraldi

Abstract

Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case-control sample (chi 2 = 2.07; p = 0.150) or in 64 nuclear families with the haplotype relative risk (HRR) design (chi 2 = 0.13; p = 0.718). Our results seem to exclude a main involvement of this variant of the dopamine D2 receptor gene in the etiopathogenesis of schizophrenia.

References

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Citations

Sep 19, 2003·Current Psychiatry Reports·Thomas W McAllister, Lanier Summerall
Dec 29, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·A SuzukiS Kaneko
Jan 27, 2004·Schizophrenia Research·Caroline DubertretPhilip Gorwood
Apr 4, 2002·Psychiatry and Clinical Neurosciences·Akio HimeiHiroshi Yoneda
Feb 12, 2009·Pharmacogenomics·Meenal GuptaRitushree Kukreti
Feb 26, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yuichiro WatanabeToshiyuki Someya
Dec 17, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jun YaoBao-jie Wang
Feb 26, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jun Yao, Bao-jie Wang
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Erik G JönssonGöran C Sedvall
Nov 11, 2016·Behavioral and Brain Functions : BBF·Thelma Beatriz González-CastroMariela Alpuin-Reyes
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ernest P Noble
Jan 13, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Stephen J Glatt, Erik G Jönsson
Jul 27, 2007·Behavioral and Brain Functions : BBF·Neetha N VijayanMoinak Banerjee

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