Abstract
Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gene associated with late-onset AD, APOE. Blood samples were obtained from members of 122 multiplex AD families, 42 unrelated cases of AD with positive family histories of dementia, 456 sporadic cases of AD, and 317 controls of similar ages at examination to the cases. These samples were genotyped for an intronic polymorphism of the PSEN1 gene, located 3' to exon 8, and the data analyzed for evidence of association or linkage. The samples were also genotyped for APOE and the data analyzed to see if the association or linkage changed when controlling for APOE genotype. There was no statistically significant increase (at alpha = .01) in allele 1 (199 bp) or genotype 1/1 in the sporadic AD cases, or in a random sample of one affected from each multiplex family, compared to controls. When examining the effect of the PSEN1 polymorphism while controlling for APOE genotype, APOE genotype was strongly associated with AD, but the PSEN1 polymorph...Continue Reading
References
Feb 21, 1991·Nature·A GoateL James
Jul 1, 1991·Analytical Biochemistry·B J BassamP M Gresshoff
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Oct 1, 1995·Nature Genetics·K OkuizumiS Tsuji
Jun 29, 1995·Nature·R SherringtonP H St George-Hyslop
Aug 18, 1995·Science·E Levy-LahadK Wang
Aug 31, 1995·Nature·E I RogaevT Tsuda
Aug 1, 1995·Nature Genetics·M I KambohS T DeKosky
Oct 1, 1994·Nature Genetics·G Thomson
May 1, 1994·Nature Genetics·C M van DuijnC Van Broeckhoven
Aug 13, 1993·Science·E H CorderM A Pericak-Vance
Aug 1, 1993·Neurology·A M SaundersM J Alberts
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Dec 1, 1995·Trends in Genetics : TIG·M A Pericak-Vance, J L Haines
Feb 24, 1996·Lancet·M WraggC Talbot
Apr 1, 1996·Genomics·J L HainesM A Pericak-Vance
Jun 1, 1996·Genomics·B M KnoppersS Lormeau
May 10, 1996·Neuroscience Letters·M L PritchardM A Pericak-Vance
Nov 1, 1996·Neuroscience·E LittleS S Schreiber
Citations
Jun 30, 2000·Biochemical and Biophysical Research Communications·K KaminoS Ohta
May 10, 1996·Neuroscience Letters·M L PritchardM A Pericak-Vance
Jan 8, 1999·Brain Research·A LiaoB T Hyman
Jul 15, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·H TanimukaiM Takeda
Sep 29, 1999·Journal of the Neurological Sciences·M BagliR Heun
Jul 25, 2000·Psychiatry Research·K OharaK Ohara
Aug 1, 1997·Neuroscience Letters·S HelisalmiH Soininen
Nov 14, 1997·Neuroscience Letters·D FallinM Mullan
May 8, 1998·Neuroscience Letters·M I KambohS T DeKosky
Aug 28, 2007·Brain Research·Miguel Rodríguez-ManotasJuan Cabezas-Herrera
Aug 17, 2004·Neuroscience Letters·Paola LucarelliPaolo Curatolo
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Miguel Rodriguez-ManotasFrancisco Cañizares-Hernandez
Oct 7, 1997·Lancet·G I KorovaitsevaE I Rogaev
Aug 30, 2006·Brain Research·Longfei JiaJianping Jia
Nov 20, 2008·Journal of Geriatric Psychiatry and Neurology·Erdinç DursunSelma Yilmazer
Aug 22, 2000·American Journal of Medical Genetics·M B PetersenM Mikkelsen
Sep 17, 2002·Molecular Psychiatry·N RiazanskaiaEl Rogaev
Apr 18, 1998·Brain Pathology·P G InceC M Morris
Sep 28, 1998·Annals of Neurology·X WangM I Kamboh