PMID: 9442805Jan 27, 1998Paper

No association or linkage to IDDM of an interferon regulatory factor-1 gene polymorphism in a Danish population. The Danish Study Group for Diabetes in Childhood

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
J JohannesenF Pociot

Abstract

Nitric oxide is a potent mediator of the cytokine-induced cytotoxic effect on pancreatic beta cells. It has been shown that the inducible nitric oxide synthase (iNOS) is induced in islets of Langerhans by interleukin-1 beta (IL-1 beta). Interferon regulatory factor-1 (IRF-1), a transcriptional factor known to play an essential role in the induction of the inducible nitric oxide synthase, has also been shown to be induced by IL-1 beta in isolated islets of Langerhans. In the present study we analysed a GT nucleotide repeat polymorphism in the intron 7 of the IRF-1 gene. We typed 123 Danish Caucasian insulin-dependent diabetes mellitus (IDDM) multiplex families (550 individuals including 271 diabetic patients) and 108 control subjects of Danish Caucasian origin. In total, seven alleles were identified. No significant differences in either allele or genotype distribution were found comparing IDDM patients with control subjects (P = 0.7 and P = 0.5, respectively). An extended transmission disequilibrium test (ETDT) did not reveal transmission disequilibrium in an allele-wise manner. A 16-nucleotide deletion was found when sequencing the region containing the polymorphic GT repeat. This new deletion was in linkage disequilibrium wit...Continue Reading

Citations

Apr 1, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stanford L Peng
Nov 1, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Leslie Van Der FitsErrol P Prens
Sep 18, 2007·Human Immunology·Yun Jong LeeYeong Wook Song
Aug 17, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·H IsmailA Scally
Sep 12, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T-N WangY-C Ko
Dec 16, 2003·Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality·Richard S ChungAntonio P Legorreta

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