No beneficial effects of resveratrol supplementation on atherogenic risk factors in patients with nonalcoholic fatty liver disease

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Laleh FarzinM Shirmohammadi

Abstract

Introduction: Cardiovascular disease (CVD) accounts as a major cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD). Resveratrol, a natural polyphenol compound, is known for its antioxidant and antiatherogenic properties and is purported to be beneficial in decreasing CVD risk factors in NAFLD patients. Objectives: This study aimed to investigate the effects of resveratrol on atherogenic risk factors in patients with NAFLD. Methods: This randomized, double-blind, placebo-controlled clinical trial was performed on 50 patients with NAFLD aged 20-60 years. Subjects were randomly assigned to receive a daily dose of 600 mg resveratrol (n = 25) or placebo (n = 25) for 12 wk. Serum liver enzymes, lipid profile and atherogenic indices, blood pressure and anthropometric values were assessed pre and post-treatment. Results: Resveratrol supplementation reduced body weight (from 88.75 ± 11.41 to 87.54 ± 11.18 kg, P = 0.005) and BMI (from 31.00 ± 3.16 to 30.60 ± 3.26 kg/m², P = 0.01) significantly compared to the placebo group. A significant reduction in waist circumference was observed within resveratrol group (from 102.70 ± 7.68 to 101.39 ± 7.62 cm, P = 0.02). There were no significant changes in lipid profile (...Continue Reading

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Citations

Jan 25, 2020·The Cochrane Database of Systematic Reviews·Maya M JeyaramanAhmed M Abou-Setta
Feb 7, 2021·Nutrients·Ludovico AbenavoliFrancesco Luzza
Dec 18, 2020·International Journal of Molecular Sciences·David E Stec, Terry D Hinds
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Jul 3, 2021·International Journal of Molecular Sciences·Shiyao ZhangSiyu Chen
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Aug 24, 2021·BMC Complementary Medicine and Therapies·Qiangqiang LiWayne Yuk-Wai Lee
Apr 28, 2020·Current Medicinal Chemistry·Mohammad BagherniyaAmirhossein Sahebkar

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
Nutritionist

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